Altered myocardial calcium cycling and energetics in heart failure - A rational approach for disease treatment

Przemek A. Gorski, Delaine K. Ceholski, Roger J. Hajjar

Research output: Contribution to journalReview articlepeer-review

149 Scopus citations

Abstract

Cardiomyocyte function depends on coordinated movements of calcium into and out of the cell and the proper delivery of ATP to energy-utilizing enzymes. Defects in calcium-handling proteins and abnormal energy metabolism are features of heart failure. Recent discoveries have led to gene-based therapies targeting calcium-transporting or -binding proteins, such as the cardiac sarco(endo)plasmic reticulum calcium ATPase (SERCA2a), leading to improvements in calcium homeostasis and excitation-contraction coupling. Here we review impaired calcium cycling and energetics in heart failure, assessing their roles from both a mutually exclusive and interdependent viewpoint, and discuss therapies that may improve the failing myocardium.

Original languageEnglish
Pages (from-to)183-194
Number of pages12
JournalCell Metabolism
Volume21
Issue number2
DOIs
StatePublished - 3 Feb 2015

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