Altered muscle electrical tissue properties in a mouse model of premature aging

Joanne Clark-Matott, Janice A. Nagy, Benjamin Sanchez, Rebecca Taylor, Daniela Riveros, Neeta A. Abraham, David K. Simon, Seward B. Rutkove

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Introduction: Improved methods are needed to detect and quantify age-related muscle change. In this study we assessed the electrical properties of muscle impacted by acquired mitochondrial DNA mutations via the PolG mouse, which exhibits typical age-associated features, and the impact of a potential therapy, nicotinamide mononucleotide (NMN). Methods: The gastrocnemii of 24 PolG and 30 wild-type (WT) mice (8 PolG and 17 WT treated with NMN) were studied in an electrical impedance-measuring cell. Conductivity and relative permittivity were determined from the impedance data. Myofiber cross-sectional area (CSA) was quantified histologically. Results: Untreated PolG mice demonstrated alterations in several impedance features, including 50-kHz relative permittivity and center frequency. A potential effect of NMN was also observed in these parameters in PolG but not WT animals. Impedance values correlated with myofiber CSA. Discussion: Electrical impedance is sensitive to myofiber features considered characteristic of aging and to the impact of a potential therapy.

Original languageEnglish
Pages (from-to)801-810
Number of pages10
JournalMuscle and Nerve
Volume60
Issue number6
DOIs
StatePublished - 1 Dec 2019
Externally publishedYes

Keywords

  • Aging
  • Impedance
  • Mitochondrial disorder
  • Muscle
  • Myofiber
  • Nicotinamide mononucleotide

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