Altered miRNA expression in the cervix during pregnancy associated with lead and mercury exposure

Alison P. Sanders; Heather H. Burris; Allan C. Just; Valeria Motta; Chitra Amarasiriwardena; Katherine Svensson; Emily Oken; Maritsa Solano-Gonzalez; Adriana Mercado-Garcia; Ivan Pantic; Joel Schwartz; Martha M. Tellez-Rojo; Andrea A. Baccarelli; Robert O. Wright

doi:10.2217/epi.15.54

Altered miRNA expression in the cervix during pregnancy associated with lead and mercury exposure

Alison P. Sanders, Heather H. Burris, Allan C. Just, Valeria Motta, Chitra Amarasiriwardena, Katherine Svensson, Emily Oken, Maritsa Solano-Gonzalez, Adriana Mercado-Garcia, Ivan Pantic, Joel Schwartz, Martha M. Tellez-Rojo, Andrea A. Baccarelli, Robert O. Wright

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49 Scopus citations

Abstract

Aim: Toxic metals including lead and mercury are associated with adverse pregnancy outcomes. This study aimed to assess the association between miRNA expression in the cervix during pregnancy with lead and mercury levels. Materials & methods: We obtained cervical swabs from pregnant women (n = 60) and quantified cervical miRNA expression. Women's blood lead, bone lead and toenail mercury levels were analyzed. We performed linear regression to examine the association between metal levels and expression of 74 miRNAs adjusting for covariates. Results: Seventeen miRNAs were negatively associated with toenail mercury levels, and tibial bone lead levels were associated with decreased expression of miR-575 and miR-4286. Conclusion: The findings highlight miRNAs in the human cervix as novel responders to maternal chemical exposure during pregnancy.

Original language	English
Pages (from-to)	885-896
Number of pages	12
Journal	Epigenomics
Volume	7
Issue number	6
DOIs	https://doi.org/10.2217/epi.15.54
State	Published - Sep 2015

Keywords

blood
bone
cervix
delivery
labor
lead
mercury
miRNA
patella
tibia

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10.2217/epi.15.54

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Sanders, A. P., Burris, H. H., Just, A. C., Motta, V., Amarasiriwardena, C., Svensson, K., Oken, E., Solano-Gonzalez, M., Mercado-Garcia, A., Pantic, I., Schwartz, J., Tellez-Rojo, M. M., Baccarelli, A. A., & Wright, R. O. (2015). Altered miRNA expression in the cervix during pregnancy associated with lead and mercury exposure. Epigenomics, 7(6), 885-896. https://doi.org/10.2217/epi.15.54

@article{bf198143b5274d52b02fe2566eb8a248,

title = "Altered miRNA expression in the cervix during pregnancy associated with lead and mercury exposure",

abstract = "Aim: Toxic metals including lead and mercury are associated with adverse pregnancy outcomes. This study aimed to assess the association between miRNA expression in the cervix during pregnancy with lead and mercury levels. Materials & methods: We obtained cervical swabs from pregnant women (n = 60) and quantified cervical miRNA expression. Women's blood lead, bone lead and toenail mercury levels were analyzed. We performed linear regression to examine the association between metal levels and expression of 74 miRNAs adjusting for covariates. Results: Seventeen miRNAs were negatively associated with toenail mercury levels, and tibial bone lead levels were associated with decreased expression of miR-575 and miR-4286. Conclusion: The findings highlight miRNAs in the human cervix as novel responders to maternal chemical exposure during pregnancy.",

keywords = "blood, bone, cervix, delivery, labor, lead, mercury, miRNA, patella, tibia",

author = "Sanders, {Alison P.} and Burris, {Heather H.} and Just, {Allan C.} and Valeria Motta and Chitra Amarasiriwardena and Katherine Svensson and Emily Oken and Maritsa Solano-Gonzalez and Adriana Mercado-Garcia and Ivan Pantic and Joel Schwartz and Tellez-Rojo, {Martha M.} and Baccarelli, {Andrea A.} and Wright, {Robert O.}",

note = "Publisher Copyright: {\textcopyright} 2015 Future Medicine Ltd.",

year = "2015",

month = sep,

doi = "10.2217/epi.15.54",

language = "English",

volume = "7",

pages = "885--896",

journal = "Epigenomics",

issn = "1750-1911",

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Sanders, AP, Burris, HH, Just, AC, Motta, V, Amarasiriwardena, C, Svensson, K, Oken, E, Solano-Gonzalez, M, Mercado-Garcia, A, Pantic, I, Schwartz, J, Tellez-Rojo, MM, Baccarelli, AA & Wright, RO 2015, 'Altered miRNA expression in the cervix during pregnancy associated with lead and mercury exposure', Epigenomics, vol. 7, no. 6, pp. 885-896. https://doi.org/10.2217/epi.15.54

TY - JOUR

T1 - Altered miRNA expression in the cervix during pregnancy associated with lead and mercury exposure

AU - Sanders, Alison P.

AU - Burris, Heather H.

AU - Just, Allan C.

AU - Motta, Valeria

AU - Amarasiriwardena, Chitra

AU - Svensson, Katherine

AU - Oken, Emily

AU - Solano-Gonzalez, Maritsa

AU - Mercado-Garcia, Adriana

AU - Pantic, Ivan

AU - Schwartz, Joel

AU - Tellez-Rojo, Martha M.

AU - Baccarelli, Andrea A.

AU - Wright, Robert O.

PY - 2015/9

Y1 - 2015/9

N2 - Aim: Toxic metals including lead and mercury are associated with adverse pregnancy outcomes. This study aimed to assess the association between miRNA expression in the cervix during pregnancy with lead and mercury levels. Materials & methods: We obtained cervical swabs from pregnant women (n = 60) and quantified cervical miRNA expression. Women's blood lead, bone lead and toenail mercury levels were analyzed. We performed linear regression to examine the association between metal levels and expression of 74 miRNAs adjusting for covariates. Results: Seventeen miRNAs were negatively associated with toenail mercury levels, and tibial bone lead levels were associated with decreased expression of miR-575 and miR-4286. Conclusion: The findings highlight miRNAs in the human cervix as novel responders to maternal chemical exposure during pregnancy.

AB - Aim: Toxic metals including lead and mercury are associated with adverse pregnancy outcomes. This study aimed to assess the association between miRNA expression in the cervix during pregnancy with lead and mercury levels. Materials & methods: We obtained cervical swabs from pregnant women (n = 60) and quantified cervical miRNA expression. Women's blood lead, bone lead and toenail mercury levels were analyzed. We performed linear regression to examine the association between metal levels and expression of 74 miRNAs adjusting for covariates. Results: Seventeen miRNAs were negatively associated with toenail mercury levels, and tibial bone lead levels were associated with decreased expression of miR-575 and miR-4286. Conclusion: The findings highlight miRNAs in the human cervix as novel responders to maternal chemical exposure during pregnancy.

KW - blood

KW - bone

KW - cervix

KW - delivery

KW - labor

KW - lead

KW - mercury

KW - miRNA

KW - patella

KW - tibia

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U2 - 10.2217/epi.15.54

DO - 10.2217/epi.15.54

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AN - SCOPUS:84947582531

SN - 1750-1911

VL - 7

SP - 885

EP - 896

JO - Epigenomics

JF - Epigenomics

IS - 6

ER -

Altered miRNA expression in the cervix during pregnancy associated with lead and mercury exposure

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Keywords

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