Altered glucose metabolism in microvessels from patients with Alzheimer's disease

David L. Marcus, Mony J. de Leon, Jeffrey Goldman, Jean Logan, David R. Christman, Alfred P. Wolf, Joanna S. Fowler, Kevin Hunter, Jir Tsai, John Pearson, Michael L. Freedman

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


Microvessels isolated from temporal of cortex of patients with Alzheimer's disease showed decreased uptake of glucose when compared with vessels from age‐matched or young control subjects. This was due to decreased hexokinase activity in the Alzheimer samples, as determined by ion exchange chromatography. This finding was confirmed independently by determination of the phosphorylation constant for hexokinase, K3, using positron emission tomography. The results suggest that Alzheimer's disease may result from a global defect in brain energy metabolism.

Original languageEnglish
Pages (from-to)91-94
Number of pages4
JournalAnnals of Neurology
Issue number1
StatePublished - Jul 1989
Externally publishedYes


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