Altered glucose metabolism in microvessels from patients with Alzheimer's disease

David L. Marcus; Mony J. de Leon; Jeffrey Goldman; Jean Logan; David R. Christman; Alfred P. Wolf; Joanna S. Fowler; Kevin Hunter; Jir Tsai; John Pearson; Michael L. Freedman

doi:10.1002/ana.410260114

Altered glucose metabolism in microvessels from patients with Alzheimer's disease

David L. Marcus, Mony J. de Leon, Jeffrey Goldman, Jean Logan, David R. Christman, Alfred P. Wolf, Joanna S. Fowler, Kevin Hunter, Jir Tsai, John Pearson, Michael L. Freedman

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53 Scopus citations

Abstract

Microvessels isolated from temporal of cortex of patients with Alzheimer's disease showed decreased uptake of glucose when compared with vessels from age‐matched or young control subjects. This was due to decreased hexokinase activity in the Alzheimer samples, as determined by ion exchange chromatography. This finding was confirmed independently by determination of the phosphorylation constant for hexokinase, K₃, using positron emission tomography. The results suggest that Alzheimer's disease may result from a global defect in brain energy metabolism.

Original language	English
Pages (from-to)	91-94
Number of pages	4
Journal	Annals of Neurology
Volume	26
Issue number	1
DOIs	https://doi.org/10.1002/ana.410260114
State	Published - Jul 1989
Externally published	Yes

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title = "Altered glucose metabolism in microvessels from patients with Alzheimer's disease",

abstract = "Microvessels isolated from temporal of cortex of patients with Alzheimer's disease showed decreased uptake of glucose when compared with vessels from age‐matched or young control subjects. This was due to decreased hexokinase activity in the Alzheimer samples, as determined by ion exchange chromatography. This finding was confirmed independently by determination of the phosphorylation constant for hexokinase, K3, using positron emission tomography. The results suggest that Alzheimer's disease may result from a global defect in brain energy metabolism.",

author = "Marcus, {David L.} and {de Leon}, {Mony J.} and Jeffrey Goldman and Jean Logan and Christman, {David R.} and Wolf, {Alfred P.} and Fowler, {Joanna S.} and Kevin Hunter and Jir Tsai and John Pearson and Freedman, {Michael L.}",

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AU - Marcus, David L.

AU - de Leon, Mony J.

AU - Goldman, Jeffrey

AU - Logan, Jean

AU - Christman, David R.

AU - Wolf, Alfred P.

AU - Fowler, Joanna S.

AU - Hunter, Kevin

AU - Tsai, Jir

AU - Pearson, John

AU - Freedman, Michael L.

PY - 1989/7

Y1 - 1989/7

N2 - Microvessels isolated from temporal of cortex of patients with Alzheimer's disease showed decreased uptake of glucose when compared with vessels from age‐matched or young control subjects. This was due to decreased hexokinase activity in the Alzheimer samples, as determined by ion exchange chromatography. This finding was confirmed independently by determination of the phosphorylation constant for hexokinase, K3, using positron emission tomography. The results suggest that Alzheimer's disease may result from a global defect in brain energy metabolism.

AB - Microvessels isolated from temporal of cortex of patients with Alzheimer's disease showed decreased uptake of glucose when compared with vessels from age‐matched or young control subjects. This was due to decreased hexokinase activity in the Alzheimer samples, as determined by ion exchange chromatography. This finding was confirmed independently by determination of the phosphorylation constant for hexokinase, K3, using positron emission tomography. The results suggest that Alzheimer's disease may result from a global defect in brain energy metabolism.

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Altered glucose metabolism in microvessels from patients with Alzheimer's disease

Abstract

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