TY - JOUR
T1 - Altered aortic properties in elderly orthostatic hypertension
AU - Hoshide, Satoshi
AU - Kario, Kazuomi
AU - Eguchi, Kazuo
AU - Ishikawa, Joji
AU - Morinari, Masato
AU - Shimada, Kazuyuki
PY - 2005/1
Y1 - 2005/1
N2 - To investigate the impact of arterial properties on orthostatic blood pressure (BP) dysregulation in older hypertensives, orthostatic BP dysregulation, a common phenomenon in elderly hypertensives, is associated with target organ damage and falls. However, the mechanism of orthostatic BP dysregulation remains unclear. The pulse wave velocity (PWV), related arterial stiffness, and the augmentation index (AI), a measure of arterial wave reflection, were measured in 365 older hypertensives. We classified the study patients into an orthostatic hypertension (OHT) group with orthostatic increase of systolic BP (SBP) of ≥20 mmHg (n=27) and an orthostatic normotension (ONT) group with an orthostatic increase of SBP of <20 mmHg and orthostatic SBP decrease of <20 mmHg (n=338). Orthostatic AI was significantly greater in the OHT group than in the ONT group (OHT: 6.5±12% vs. ONT: -5.6±12%, p<0.001), while supine AI and supine and orthostatic pulse rate were comparable between the two groups. There was no significant difference in the PWV between the OHT and ONT groups. Orthostatic hypertension was affected by altered aortic properties and associated with augmented wave reflection of arterial pressure.
AB - To investigate the impact of arterial properties on orthostatic blood pressure (BP) dysregulation in older hypertensives, orthostatic BP dysregulation, a common phenomenon in elderly hypertensives, is associated with target organ damage and falls. However, the mechanism of orthostatic BP dysregulation remains unclear. The pulse wave velocity (PWV), related arterial stiffness, and the augmentation index (AI), a measure of arterial wave reflection, were measured in 365 older hypertensives. We classified the study patients into an orthostatic hypertension (OHT) group with orthostatic increase of systolic BP (SBP) of ≥20 mmHg (n=27) and an orthostatic normotension (ONT) group with an orthostatic increase of SBP of <20 mmHg and orthostatic SBP decrease of <20 mmHg (n=338). Orthostatic AI was significantly greater in the OHT group than in the ONT group (OHT: 6.5±12% vs. ONT: -5.6±12%, p<0.001), while supine AI and supine and orthostatic pulse rate were comparable between the two groups. There was no significant difference in the PWV between the OHT and ONT groups. Orthostatic hypertension was affected by altered aortic properties and associated with augmented wave reflection of arterial pressure.
KW - Aortic properties
KW - Augmentation index
KW - Orthostatic hypertension
UR - http://www.scopus.com/inward/record.url?scp=17844393972&partnerID=8YFLogxK
U2 - 10.1291/hypres.28.15
DO - 10.1291/hypres.28.15
M3 - Article
C2 - 15969250
AN - SCOPUS:17844393972
SN - 0916-9636
VL - 28
SP - 15
EP - 19
JO - Hypertension Research
JF - Hypertension Research
IS - 1
ER -