Alterations of the human gut microbiome in multiple sclerosis

Sushrut Jangi; Roopali Gandhi; Laura M. Cox; Ning Li; Felipe Von Glehn; Raymond Yan; Bonny Patel; Maria Antonietta Mazzola; Shirong Liu; Bonnie L. Glanz; Sandra Cook; Stephanie Tankou; Fiona Stuart; Kirsy Melo; Parham Nejad; Kathleen Smith; Begüm D. Topçuolu; James Holden; Pia Kivisäkk; Tanuja Chitnis; Philip L. De Jager; Francisco J. Quintana; Georg K. Gerber; Lynn Bry; Howard L. Weiner

doi:10.1038/ncomms12015

Alterations of the human gut microbiome in multiple sclerosis

Sushrut Jangi, Roopali Gandhi, Laura M. Cox, Ning Li, Felipe Von Glehn, Raymond Yan, Bonny Patel, Maria Antonietta Mazzola, Shirong Liu, Bonnie L. Glanz, Sandra Cook, Stephanie Tankou, Fiona Stuart, Kirsy Melo, Parham Nejad, Kathleen Smith, Begüm D. Topçuolu, James Holden, Pia Kivisäkk, Tanuja ChitnisPhilip L. De Jager, Francisco J. Quintana, Georg K. Gerber, Lynn Bry, Howard L. Weiner

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1054 Scopus citations

Abstract

The gut microbiome plays an important role in immune function and has been implicated in several autoimmune disorders. Here we use 16S rRNA sequencing to investigate the gut microbiome in subjects with multiple sclerosis (MS, n=60) and healthy controls (n=43). Microbiome alterations in MS include increases in Methanobrevibacter and Akkermansia and decreases in Butyricimonas, and correlate with variations in the expression of genes involved in dendritic cell maturation, interferon signalling and NF-kB signalling pathways in circulating T cells and monocytes. Patients on disease-modifying treatment show increased abundances of Prevotella and Sutterella, and decreased Sarcina, compared with untreated patients. MS patients of a second cohort show elevated breath methane compared with controls, consistent with our observation of increased gut Methanobrevibacter in MS in the first cohort. Further study is required to assess whether the observed alterations in the gut microbiome play a role in, or are a consequence of, MS pathogenesis.

Original language	English
Article number	12015
Journal	Nature Communications
Volume	7
DOIs	https://doi.org/10.1038/ncomms12015
State	Published - 28 Jun 2016
Externally published	Yes

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Jangi, S., Gandhi, R., Cox, L. M., Li, N., Von Glehn, F., Yan, R., Patel, B., Mazzola, M. A., Liu, S., Glanz, B. L., Cook, S., Tankou, S., Stuart, F., Melo, K., Nejad, P., Smith, K., Topçuolu, B. D., Holden, J., Kivisäkk, P., ... Weiner, H. L. (2016). Alterations of the human gut microbiome in multiple sclerosis. Nature Communications, 7, Article 12015. https://doi.org/10.1038/ncomms12015

@article{883c0e38cee1429ba59f95072cf0e543,

title = "Alterations of the human gut microbiome in multiple sclerosis",

abstract = "The gut microbiome plays an important role in immune function and has been implicated in several autoimmune disorders. Here we use 16S rRNA sequencing to investigate the gut microbiome in subjects with multiple sclerosis (MS, n=60) and healthy controls (n=43). Microbiome alterations in MS include increases in Methanobrevibacter and Akkermansia and decreases in Butyricimonas, and correlate with variations in the expression of genes involved in dendritic cell maturation, interferon signalling and NF-kB signalling pathways in circulating T cells and monocytes. Patients on disease-modifying treatment show increased abundances of Prevotella and Sutterella, and decreased Sarcina, compared with untreated patients. MS patients of a second cohort show elevated breath methane compared with controls, consistent with our observation of increased gut Methanobrevibacter in MS in the first cohort. Further study is required to assess whether the observed alterations in the gut microbiome play a role in, or are a consequence of, MS pathogenesis.",

author = "Sushrut Jangi and Roopali Gandhi and Cox, \{Laura M.\} and Ning Li and \{Von Glehn\}, Felipe and Raymond Yan and Bonny Patel and Mazzola, \{Maria Antonietta\} and Shirong Liu and Glanz, \{Bonnie L.\} and Sandra Cook and Stephanie Tankou and Fiona Stuart and Kirsy Melo and Parham Nejad and Kathleen Smith and Top{\c c}uolu, \{Beg{\"u}m D.\} and James Holden and Pia Kivis{\"a}kk and Tanuja Chitnis and \{De Jager\}, \{Philip L.\} and Quintana, \{Francisco J.\} and Gerber, \{Georg K.\} and Lynn Bry and Weiner, \{Howard L.\}",

year = "2016",

month = jun,

day = "28",

doi = "10.1038/ncomms12015",

language = "English",

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journal = "Nature Communications",

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Jangi, S, Gandhi, R, Cox, LM, Li, N, Von Glehn, F, Yan, R, Patel, B, Mazzola, MA, Liu, S, Glanz, BL, Cook, S, Tankou, S, Stuart, F, Melo, K, Nejad, P, Smith, K, Topçuolu, BD, Holden, J, Kivisäkk, P, Chitnis, T, De Jager, PL, Quintana, FJ, Gerber, GK, Bry, L & Weiner, HL 2016, 'Alterations of the human gut microbiome in multiple sclerosis', Nature Communications, vol. 7, 12015. https://doi.org/10.1038/ncomms12015

TY - JOUR

T1 - Alterations of the human gut microbiome in multiple sclerosis

AU - Jangi, Sushrut

AU - Gandhi, Roopali

AU - Cox, Laura M.

AU - Li, Ning

AU - Von Glehn, Felipe

AU - Yan, Raymond

AU - Patel, Bonny

AU - Mazzola, Maria Antonietta

AU - Liu, Shirong

AU - Glanz, Bonnie L.

AU - Cook, Sandra

AU - Tankou, Stephanie

AU - Stuart, Fiona

AU - Melo, Kirsy

AU - Nejad, Parham

AU - Smith, Kathleen

AU - Topçuolu, Begüm D.

AU - Holden, James

AU - Kivisäkk, Pia

AU - Chitnis, Tanuja

AU - De Jager, Philip L.

AU - Quintana, Francisco J.

AU - Gerber, Georg K.

AU - Bry, Lynn

AU - Weiner, Howard L.

PY - 2016/6/28

Y1 - 2016/6/28

N2 - The gut microbiome plays an important role in immune function and has been implicated in several autoimmune disorders. Here we use 16S rRNA sequencing to investigate the gut microbiome in subjects with multiple sclerosis (MS, n=60) and healthy controls (n=43). Microbiome alterations in MS include increases in Methanobrevibacter and Akkermansia and decreases in Butyricimonas, and correlate with variations in the expression of genes involved in dendritic cell maturation, interferon signalling and NF-kB signalling pathways in circulating T cells and monocytes. Patients on disease-modifying treatment show increased abundances of Prevotella and Sutterella, and decreased Sarcina, compared with untreated patients. MS patients of a second cohort show elevated breath methane compared with controls, consistent with our observation of increased gut Methanobrevibacter in MS in the first cohort. Further study is required to assess whether the observed alterations in the gut microbiome play a role in, or are a consequence of, MS pathogenesis.

AB - The gut microbiome plays an important role in immune function and has been implicated in several autoimmune disorders. Here we use 16S rRNA sequencing to investigate the gut microbiome in subjects with multiple sclerosis (MS, n=60) and healthy controls (n=43). Microbiome alterations in MS include increases in Methanobrevibacter and Akkermansia and decreases in Butyricimonas, and correlate with variations in the expression of genes involved in dendritic cell maturation, interferon signalling and NF-kB signalling pathways in circulating T cells and monocytes. Patients on disease-modifying treatment show increased abundances of Prevotella and Sutterella, and decreased Sarcina, compared with untreated patients. MS patients of a second cohort show elevated breath methane compared with controls, consistent with our observation of increased gut Methanobrevibacter in MS in the first cohort. Further study is required to assess whether the observed alterations in the gut microbiome play a role in, or are a consequence of, MS pathogenesis.

UR - https://www.scopus.com/pages/publications/84976612100

U2 - 10.1038/ncomms12015

DO - 10.1038/ncomms12015

M3 - Article

C2 - 27352007

AN - SCOPUS:84976612100

SN - 2041-1723

VL - 7

JO - Nature Communications

JF - Nature Communications

M1 - 12015

ER -

Alterations of the human gut microbiome in multiple sclerosis

Abstract

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