Alterations of metabolic genes and metabolites in cancer

Eric K. Oermann; Jing Wu; Kun Liang Guan; Yue Xiong

doi:10.1016/j.semcdb.2012.01.013

Alterations of metabolic genes and metabolites in cancer

Eric K. Oermann, Jing Wu, Kun Liang Guan, Yue Xiong

Research output: Contribution to journal › Review article › peer-review

107 Scopus citations

Abstract

Altered metabolic regulation has long been observed in human cancer and broadly used in the clinic for tumor detection. Two recent findings-the direct regulation of metabolic enzymes by frequently mutated cancer genes and frequent mutations of several metabolic enzymes themselves in cancer-have renewed interest in cancer metabolism. Supporting a causative role of altered metabolic enzymes in tumorigenesis, abnormal levels of several metabolites have been found to play a direct role in cancer development. The alteration of metabolic genes and metabolites offer not only new biomarkers for diagnosis and prognosis, but also potential new targets for cancer therapy.

Original language	English
Pages (from-to)	370-380
Number of pages	11
Journal	Seminars in Cell and Developmental Biology
Volume	23
Issue number	4
DOIs	https://doi.org/10.1016/j.semcdb.2012.01.013
State	Published - Jun 2012
Externally published	Yes

Keywords

Cancer
Metabolism
Oncometabolite
Tumorigenesis
Warburg

Access to Document

10.1016/j.semcdb.2012.01.013

Cite this

@article{34e29f51a9564009b6685141e484fae4,

title = "Alterations of metabolic genes and metabolites in cancer",

abstract = "Altered metabolic regulation has long been observed in human cancer and broadly used in the clinic for tumor detection. Two recent findings-the direct regulation of metabolic enzymes by frequently mutated cancer genes and frequent mutations of several metabolic enzymes themselves in cancer-have renewed interest in cancer metabolism. Supporting a causative role of altered metabolic enzymes in tumorigenesis, abnormal levels of several metabolites have been found to play a direct role in cancer development. The alteration of metabolic genes and metabolites offer not only new biomarkers for diagnosis and prognosis, but also potential new targets for cancer therapy.",

keywords = "Cancer, Metabolism, Oncometabolite, Tumorigenesis, Warburg",

author = "Oermann, \{Eric K.\} and Jing Wu and Guan, \{Kun Liang\} and Yue Xiong",

note = "Funding Information: J.W. is supported by a National Cancer Institute NIH K-12 career development grant to the University of North Carolina at Chapel Hill. E.K.O. is supported by a Doris Duke Charitable Foundation Clinical Research Fellowship. This study is supported by NIH grants to K.L.G and Y.X.",

year = "2012",

month = jun,

doi = "10.1016/j.semcdb.2012.01.013",

language = "English",

volume = "23",

pages = "370--380",

journal = "Seminars in Cell and Developmental Biology",

issn = "1084-9521",

publisher = "Elsevier Ltd.",

number = "4",

}

TY - JOUR

T1 - Alterations of metabolic genes and metabolites in cancer

AU - Oermann, Eric K.

AU - Wu, Jing

AU - Guan, Kun Liang

AU - Xiong, Yue

N1 - Funding Information: J.W. is supported by a National Cancer Institute NIH K-12 career development grant to the University of North Carolina at Chapel Hill. E.K.O. is supported by a Doris Duke Charitable Foundation Clinical Research Fellowship. This study is supported by NIH grants to K.L.G and Y.X.

PY - 2012/6

Y1 - 2012/6

N2 - Altered metabolic regulation has long been observed in human cancer and broadly used in the clinic for tumor detection. Two recent findings-the direct regulation of metabolic enzymes by frequently mutated cancer genes and frequent mutations of several metabolic enzymes themselves in cancer-have renewed interest in cancer metabolism. Supporting a causative role of altered metabolic enzymes in tumorigenesis, abnormal levels of several metabolites have been found to play a direct role in cancer development. The alteration of metabolic genes and metabolites offer not only new biomarkers for diagnosis and prognosis, but also potential new targets for cancer therapy.

AB - Altered metabolic regulation has long been observed in human cancer and broadly used in the clinic for tumor detection. Two recent findings-the direct regulation of metabolic enzymes by frequently mutated cancer genes and frequent mutations of several metabolic enzymes themselves in cancer-have renewed interest in cancer metabolism. Supporting a causative role of altered metabolic enzymes in tumorigenesis, abnormal levels of several metabolites have been found to play a direct role in cancer development. The alteration of metabolic genes and metabolites offer not only new biomarkers for diagnosis and prognosis, but also potential new targets for cancer therapy.

KW - Cancer

KW - Metabolism

KW - Oncometabolite

KW - Tumorigenesis

KW - Warburg

UR - https://www.scopus.com/pages/publications/84862776612

U2 - 10.1016/j.semcdb.2012.01.013

DO - 10.1016/j.semcdb.2012.01.013

M3 - Review article

AN - SCOPUS:84862776612

SN - 1084-9521

VL - 23

SP - 370

EP - 380

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

IS - 4

ER -

Alterations of metabolic genes and metabolites in cancer

Abstract

Keywords

Access to Document

Fingerprint

Cite this