Alterations in the cutaneous microbiome of patients with psoriasis and psoriatic arthritis reveal similarities between non-lesional and lesional skin

Alba Boix-Amorós, Michelle H. Badri, Julia Manasson, Rebecca B. Blank, Rebecca H. Haberman, Andrea L. Neimann, Parvathy V. Girija, Anthony Jimenez Hernandez, Adriana Heguy, Sergei B. Koralov, Richard Bonneau, Jose C. Clemente, Jose U. Scher

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Objectives To investigate the cutaneous microbiome spanning the entire psoriatic disease spectrum, and to evaluate distinguishing features of psoriasis (PsO) and psoriatic arthritis (PsA). Methods Skin swabs were collected from upper and lower extremities of healthy individuals and patients with PsO and PsA. Psoriatic patients contributed both lesional (L) and contralateral non-lesional (NL) samples. Microbiota were analysed using 16S rRNA sequencing. Results Compared with healthy skin, alpha diversity in psoriatic NL and L skin was significantly reduced (p<0.05) and samples clustered separately in plots of beta diversity (p<0.05). Kocuria and Cutibacterium were enriched in healthy subjects, while Staphylococcus was enriched in psoriatic disease. Microbe-microbe association networks revealed a higher degree of similarity between psoriatic NL and L skin compared with healthy skin despite the absence of clinically evident inflammation. Moreover, the relative abundance of Corynebacterium was higher in NL PsA samples compared with NL PsO samples (p<0.05), potentially serving as a biomarker for disease progression. Conclusions These findings show differences in diversity, bacterial composition and microbe-microbe interactions between healthy and psoriatic skin, both L and NL. We further identified bacterial biomarkers that differentiate disease phenotypes, which could potentially aid in predicting the transition from PsO to PsA.

Original languageEnglish
Pages (from-to)507-514
Number of pages8
JournalAnnals of the Rheumatic Diseases
Volume82
Issue number4
DOIs
StatePublished - 1 Apr 2023

Keywords

  • Arthritis, Psoriatic
  • Autoimmune Diseases
  • Epidemiology

Fingerprint

Dive into the research topics of 'Alterations in the cutaneous microbiome of patients with psoriasis and psoriatic arthritis reveal similarities between non-lesional and lesional skin'. Together they form a unique fingerprint.

Cite this