Alterations in hypothalamic serotonergic-catecholaminergic relationships in aging C57BL/6J female mice

Nancy Telford; Charles V. Mobbs; Heinz H. Osterburg; Caleb E. Finch

doi:10.1016/0531-5565(88)90060-5

Alterations in hypothalamic serotonergic-catecholaminergic relationships in aging C57BL/6J female mice

Nancy Telford
, Charles V. Mobbs
, Heinz H. Osterburg
, Caleb E. Finch

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The effects of aging and estradiol on the three major hypothalamic monoaminergic systems were measured in female C57BL/6J mice. Both aging and estradiol treatment induced small (10-15%) changes in the levels and ratios of the monoamines and their catabolites. In addition, the levels of 5-hydroxyindoleacetic acid, the major serotonergic catabolite, were strongly correlated with the levels of the two major dopaminergic catabolites, 3,4-dihydrophenylacetic acid and homovanillic acid. Aging affected the relattionship between 5-hydroxyindoleacetic acid and the dopaminergic catabolites such that the slope of the regression lines of 5-hydroxyindoleacetic acid on the dopaminergic compounds was increased in order mice. The age-related alteration in the correlations between the serotonergic and dopaminergic compounds may be due to an effect of aging on the acid export system.

Original language	English
Pages (from-to)	481-489
Number of pages	9
Journal	Experimental Gerontology
Volume	23
Issue number	6
DOIs	https://doi.org/10.1016/0531-5565(88)90060-5
State	Published - 1988
Externally published	Yes

Keywords

aging
dopamine
hypothalamus
norepinephrine
serotonin

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10.1016/0531-5565(88)90060-5

Cite this

@article{505b845fca3c46348778f377d10a09f6,

title = "Alterations in hypothalamic serotonergic-catecholaminergic relationships in aging C57BL/6J female mice",

abstract = "The effects of aging and estradiol on the three major hypothalamic monoaminergic systems were measured in female C57BL/6J mice. Both aging and estradiol treatment induced small (10-15\%) changes in the levels and ratios of the monoamines and their catabolites. In addition, the levels of 5-hydroxyindoleacetic acid, the major serotonergic catabolite, were strongly correlated with the levels of the two major dopaminergic catabolites, 3,4-dihydrophenylacetic acid and homovanillic acid. Aging affected the relattionship between 5-hydroxyindoleacetic acid and the dopaminergic catabolites such that the slope of the regression lines of 5-hydroxyindoleacetic acid on the dopaminergic compounds was increased in order mice. The age-related alteration in the correlations between the serotonergic and dopaminergic compounds may be due to an effect of aging on the acid export system.",

keywords = "aging, dopamine, hypothalamus, norepinephrine, serotonin",

author = "Nancy Telford and Mobbs, \{Charles V.\} and Osterburg, \{Heinz H.\} and Finch, \{Caleb E.\}",

note = "Funding Information: Acknowledgments - This work was supported by NIH training grant AG-00093 (NT, CVM) and by NIH grant AG-00443 (CEF). Portions of this work were presented at the Thirteenth Annual Meeting of the Society for Neuroscience (Telford et al., 1983) and at the Sixteenth Annual Meeting of the American Society for Neurochemistry (Telford et al., 1985).",

year = "1988",

doi = "10.1016/0531-5565(88)90060-5",

language = "English",

volume = "23",

pages = "481--489",

journal = "Experimental Gerontology",

issn = "0531-5565",

publisher = "Elsevier Inc.",

number = "6",

}

TY - JOUR

T1 - Alterations in hypothalamic serotonergic-catecholaminergic relationships in aging C57BL/6J female mice

AU - Telford, Nancy

AU - Mobbs, Charles V.

AU - Osterburg, Heinz H.

AU - Finch, Caleb E.

N1 - Funding Information: Acknowledgments - This work was supported by NIH training grant AG-00093 (NT, CVM) and by NIH grant AG-00443 (CEF). Portions of this work were presented at the Thirteenth Annual Meeting of the Society for Neuroscience (Telford et al., 1983) and at the Sixteenth Annual Meeting of the American Society for Neurochemistry (Telford et al., 1985).

PY - 1988

Y1 - 1988

N2 - The effects of aging and estradiol on the three major hypothalamic monoaminergic systems were measured in female C57BL/6J mice. Both aging and estradiol treatment induced small (10-15%) changes in the levels and ratios of the monoamines and their catabolites. In addition, the levels of 5-hydroxyindoleacetic acid, the major serotonergic catabolite, were strongly correlated with the levels of the two major dopaminergic catabolites, 3,4-dihydrophenylacetic acid and homovanillic acid. Aging affected the relattionship between 5-hydroxyindoleacetic acid and the dopaminergic catabolites such that the slope of the regression lines of 5-hydroxyindoleacetic acid on the dopaminergic compounds was increased in order mice. The age-related alteration in the correlations between the serotonergic and dopaminergic compounds may be due to an effect of aging on the acid export system.

AB - The effects of aging and estradiol on the three major hypothalamic monoaminergic systems were measured in female C57BL/6J mice. Both aging and estradiol treatment induced small (10-15%) changes in the levels and ratios of the monoamines and their catabolites. In addition, the levels of 5-hydroxyindoleacetic acid, the major serotonergic catabolite, were strongly correlated with the levels of the two major dopaminergic catabolites, 3,4-dihydrophenylacetic acid and homovanillic acid. Aging affected the relattionship between 5-hydroxyindoleacetic acid and the dopaminergic catabolites such that the slope of the regression lines of 5-hydroxyindoleacetic acid on the dopaminergic compounds was increased in order mice. The age-related alteration in the correlations between the serotonergic and dopaminergic compounds may be due to an effect of aging on the acid export system.

KW - aging

KW - dopamine

KW - hypothalamus

KW - norepinephrine

KW - serotonin

UR - https://www.scopus.com/pages/publications/0024206420

U2 - 10.1016/0531-5565(88)90060-5

DO - 10.1016/0531-5565(88)90060-5

M3 - Article

C2 - 3250884

AN - SCOPUS:0024206420

SN - 0531-5565

VL - 23

SP - 481

EP - 489

JO - Experimental Gerontology

JF - Experimental Gerontology

IS - 6

ER -

Alterations in hypothalamic serotonergic-catecholaminergic relationships in aging C57BL/6J female mice

Abstract

Keywords

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