TY - JOUR
T1 - Alterations in glycolysis and activity of glucose 6 phosphate dehydrogenase in experimental cirrhosis of liver tissue (Russian)
AU - Potekhinskaya, T. V.
AU - Tsyrlov, I. B.
AU - Lyakhovich, V. V.G.S.
PY - 1975
Y1 - 1975
N2 - The development of experimental cirrhosis of the liver during chronic poisoning with carbon tetrachloride did not influence the intensity of glycolysis, with glucose as a substrate, in the supernatant fraction of the liver homogenate. In preparations of cirrhotic liver, as compared with liver from intact animals, more distinct activation of glycolysis was caused by addition of ATP and NAD at the stage of 3 wk poisoning and also by addition of hexokinase, glyceraldehyde phosphate dehydrogenase and lactate dehydrogenase at the stage of distinct cirrhosis of the liver (6 wk of CCl4 poisoning). K(m) values for glucose 6 phosphate dehydrogenase increased at all the periods of poisoning.
AB - The development of experimental cirrhosis of the liver during chronic poisoning with carbon tetrachloride did not influence the intensity of glycolysis, with glucose as a substrate, in the supernatant fraction of the liver homogenate. In preparations of cirrhotic liver, as compared with liver from intact animals, more distinct activation of glycolysis was caused by addition of ATP and NAD at the stage of 3 wk poisoning and also by addition of hexokinase, glyceraldehyde phosphate dehydrogenase and lactate dehydrogenase at the stage of distinct cirrhosis of the liver (6 wk of CCl4 poisoning). K(m) values for glucose 6 phosphate dehydrogenase increased at all the periods of poisoning.
UR - https://www.scopus.com/pages/publications/0016654042
M3 - Article
C2 - 164085
AN - SCOPUS:0016654042
SN - 0042-8809
VL - 21
SP - 70
EP - 73
JO - Biomeditsinskaya Khimiya
JF - Biomeditsinskaya Khimiya
IS - 1
ER -