Alterations in event-related potentials (ERPs) of MPTP-treated monkeys

Andrew Glover, M. Felice Ghilardi, Ivan Bodis-Wollner, Marco Onofrj

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Using an auditory 'oddball' paradigm and classical conditioning, we have studied auditory evoked potentials (AEPs) and P300-like potentials in monkeys pre- and post-MPTP treatment. Free-field acoustic stimuli were 500 Hz and 4000 Hz tones, which were designated as the 'frequent' and 'rare' conditions, respectively. The 4000 Hz stimuli were reinforced with mild somatosensory electrical stimulation. During the first few weeks following 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) administration, all monkeys gradually developed a parkinsonian syndrome, which partially, but not completely improved within 30-40 days in 2 animals. The amplitudes of the AEP were initially significantly decreased, but progressively returned to pretreatment magnitudes in the 2 monkeys which partially recovered. P300-like potentials were initially abolished in all animals; however, 30-40 days later P300 spontaneously re-emerged in the same 2 monkeys. Latencies of both of these signals were unaffected by MPTP. Acute administration of dopamine precursor during the first phase of neurotoxicity partially and temporarily improved depressed AEP amplitudes, but did not restore absent P300-like potentials. The relevance of these results for Parkinson's disease is discussed.

Original languageEnglish
Pages (from-to)461-468
Number of pages8
JournalElectroencephalography and Clinical Neurophysiology/ Evoked Potentials
Volume71
Issue number6
DOIs
StatePublished - 1988

Keywords

  • 1-Methyl-3-phenyl-1,2,5,6-tetrahydropyridine
  • AEP
  • Dopamine
  • Monkey
  • P300
  • Parkinson's disease

Fingerprint

Dive into the research topics of 'Alterations in event-related potentials (ERPs) of MPTP-treated monkeys'. Together they form a unique fingerprint.

Cite this