Alterations in cortisol negative feedback inhibition as examined using the ACTH response to cortisol administration in PTSD

Rachel Yehuda, Ren Kui Yang, Monte S. Buchsbaum, Julia A. Golier

Research output: Contribution to journalArticlepeer-review

84 Scopus citations

Abstract

Objective: Studies using the dexamethasone suppression test (DST) have demonstrated an enhanced negative feedback inhibition at the pituitary in PTSD, but have not provided information about central feedback effects, since dexamethasone (DEX) does not penetrate the brain well. The authors therefore examined the change in ACTH and cortisol before and after cortisol administration, which acts at central feedback sites in addition to peripheral targets. Method: Blood was obtained from 31 male veterans (18 with PTSD) before, and 8, 40 and 95 min following injection of 17.5 mg cortisol and placebo. Results: A greater decline in ACTH was observed after cortisol injection in PTSD. Conclusions: Central as well as peripheral negative feedback inhibition may be altered in PTSD.

Original languageEnglish
Pages (from-to)447-451
Number of pages5
JournalPsychoneuroendocrinology
Volume31
Issue number4
DOIs
StatePublished - May 2006
Externally publishedYes

Keywords

  • ACTH
  • Cortisol
  • Glucocorticoid receptor
  • Hypothalamic-pituitary-adrenal axis
  • Negative feedback inhibition
  • PTSD

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