Alterations in cerebrospinal fluid dopamine metabolites following physostigmine infusion

Kenneth L. Davis; Kym F. Faull; Leo E. Hollister; Jack D. Barchas; Philip A. Berger

doi:10.1007/BF00431649

Alterations in cerebrospinal fluid dopamine metabolites following physostigmine infusion

Kenneth L. Davis, Kym F. Faull, Leo E. Hollister, Jack D. Barchas, Philip A. Berger

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The effect of IV physostigmine administration on the cerebrospinal fluid (CSF) levels of homovanillic acid (HVA) and dihydroxyphenylacetic acid (DOPAC) in normal subjects was determined. After an adjustment for differing CSF concentrations of probenecid, physostigmine was found to elevate CSF HVA and DOPAC concentrations. The authors discuss these changes in CSF HVA and DOPAC and their possible relationship to the ability of physostigmine to decrease the symptoms of some patients with tardive dyskinesia.

Original language	English
Pages (from-to)	155-160
Number of pages	6
Journal	Psychopharmacology
Volume	72
Issue number	2
DOIs	https://doi.org/10.1007/BF00431649
State	Published - Jan 1981

Keywords

Cerebrospinal fluid
Dopamine metabolites
Physostigmine infusion
Tardive dyskinesia

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10.1007/BF00431649

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title = "Alterations in cerebrospinal fluid dopamine metabolites following physostigmine infusion",

abstract = "The effect of IV physostigmine administration on the cerebrospinal fluid (CSF) levels of homovanillic acid (HVA) and dihydroxyphenylacetic acid (DOPAC) in normal subjects was determined. After an adjustment for differing CSF concentrations of probenecid, physostigmine was found to elevate CSF HVA and DOPAC concentrations. The authors discuss these changes in CSF HVA and DOPAC and their possible relationship to the ability of physostigmine to decrease the symptoms of some patients with tardive dyskinesia.",

keywords = "Cerebrospinal fluid, Dopamine metabolites, Physostigmine infusion, Tardive dyskinesia",

author = "Davis, \{Kenneth L.\} and Faull, \{Kym F.\} and Hollister, \{Leo E.\} and Barchas, \{Jack D.\} and Berger, \{Philip A.\}",

year = "1981",

month = jan,

doi = "10.1007/BF00431649",

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volume = "72",

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T1 - Alterations in cerebrospinal fluid dopamine metabolites following physostigmine infusion

AU - Davis, Kenneth L.

AU - Faull, Kym F.

AU - Hollister, Leo E.

AU - Barchas, Jack D.

AU - Berger, Philip A.

PY - 1981/1

Y1 - 1981/1

N2 - The effect of IV physostigmine administration on the cerebrospinal fluid (CSF) levels of homovanillic acid (HVA) and dihydroxyphenylacetic acid (DOPAC) in normal subjects was determined. After an adjustment for differing CSF concentrations of probenecid, physostigmine was found to elevate CSF HVA and DOPAC concentrations. The authors discuss these changes in CSF HVA and DOPAC and their possible relationship to the ability of physostigmine to decrease the symptoms of some patients with tardive dyskinesia.

AB - The effect of IV physostigmine administration on the cerebrospinal fluid (CSF) levels of homovanillic acid (HVA) and dihydroxyphenylacetic acid (DOPAC) in normal subjects was determined. After an adjustment for differing CSF concentrations of probenecid, physostigmine was found to elevate CSF HVA and DOPAC concentrations. The authors discuss these changes in CSF HVA and DOPAC and their possible relationship to the ability of physostigmine to decrease the symptoms of some patients with tardive dyskinesia.

KW - Cerebrospinal fluid

KW - Dopamine metabolites

KW - Physostigmine infusion

KW - Tardive dyskinesia

UR - https://www.scopus.com/pages/publications/0019463204

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DO - 10.1007/BF00431649

M3 - Article

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SN - 0033-3158

VL - 72

SP - 155

EP - 160

JO - Psychopharmacology

JF - Psychopharmacology

IS - 2

ER -

Alterations in cerebrospinal fluid dopamine metabolites following physostigmine infusion

Abstract

Keywords

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