Alteration of escape from rewarding electrical brain stimulation by d-amphetamine

Solomon S. Steiner, Robert F. Ackermann, Richard J. Bodnar, Frances Jackler, Jane M. Healey, Steven J. Ellman

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Rats were trained both to barpress for and escape from locus coeruleus, midbrain periaqueductal gray and hypothalamic stimulation. Rate-intensity functions for intracranial self-stimulation (ICSS) behavior and latency-intensity functions for escape behavior were obtained for each electrode site in each animal. Following baseline, d-amphetamine was administered and responding was compared with the saline condition for both rate-intensity and latency-intensity functions. ICSS response rates were enhanced by d-amphetamine at all loci, particularly at threshold intensities, while escape responding was biphasically affected by d-amphetamine at all loci. D-amphetamine increased escape latencies at intensities which, under saline, elicited short escape latencies, while decreasing escape latencies at intensities which, under saline, elicited long escape latencies. A significant correspondence was noted between intensities which, under the influence of d-amphetamine, both elicited longer escape latencies and higher ICSS response rates, suggesting that in both ICSS and escape paradigms, animals were titrating the duration of the stimulus train. No site-specific effects of d-amphetamine upon escape behavior were noted.

Original languageEnglish
Pages (from-to)19-23
Number of pages5
JournalInternational Journal of Neuroscience
Volume7
Issue number1
DOIs
StatePublished - 1976
Externally publishedYes

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