Alteration in systemic vascular resistance and cardiac output during acute cellular rejection and recovery in heart transplant recipients

Arthur R. Garan; Nir Uriel; Gabriel Sayer; Daniel Sims; Doris Zahner; Maryjane Farr; Donna Mancini; Ulrich P. Jorde

doi:10.1016/j.healun.2009.08.015

Alteration in systemic vascular resistance and cardiac output during acute cellular rejection and recovery in heart transplant recipients

Arthur R. Garan, Nir Uriel, Gabriel Sayer, Daniel Sims, Doris Zahner, Maryjane Farr, Donna Mancini, Ulrich P. Jorde

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Coronary vascular reserve is impaired during acute cellular rejection of the orthotopically transplanted heart, but changes in the peripheral vasculature during rejection have not been well described. To investigate whether peripheral vascular compensatory mechanisms are preserved after orthotopic heart transplantation (OHT), we longitudinally observed systemic vascular resistance (SVR) and cardiac output (CO) during acute cellular rejection. CO decreased during high-grade acute cellular rejection, and maintenance of mean arterial pressure was achieved by increases in SVR, and these changes did not return to baseline until several months after histologic resolution of rejection.

Original language	English
Pages (from-to)	382-384
Number of pages	3
Journal	Journal of Heart and Lung Transplantation
Volume	29
Issue number	3
DOIs	https://doi.org/10.1016/j.healun.2009.08.015
State	Published - Mar 2010
Externally published	Yes

Keywords

heart transplantation
hemodynamics
rejection
systemic vascular resistance

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10.1016/j.healun.2009.08.015

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title = "Alteration in systemic vascular resistance and cardiac output during acute cellular rejection and recovery in heart transplant recipients",

abstract = "Coronary vascular reserve is impaired during acute cellular rejection of the orthotopically transplanted heart, but changes in the peripheral vasculature during rejection have not been well described. To investigate whether peripheral vascular compensatory mechanisms are preserved after orthotopic heart transplantation (OHT), we longitudinally observed systemic vascular resistance (SVR) and cardiac output (CO) during acute cellular rejection. CO decreased during high-grade acute cellular rejection, and maintenance of mean arterial pressure was achieved by increases in SVR, and these changes did not return to baseline until several months after histologic resolution of rejection.",

keywords = "heart transplantation, hemodynamics, rejection, systemic vascular resistance",

author = "Garan, {Arthur R.} and Nir Uriel and Gabriel Sayer and Daniel Sims and Doris Zahner and Maryjane Farr and Donna Mancini and Jorde, {Ulrich P.}",

year = "2010",

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doi = "10.1016/j.healun.2009.08.015",

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T1 - Alteration in systemic vascular resistance and cardiac output during acute cellular rejection and recovery in heart transplant recipients

AU - Garan, Arthur R.

AU - Uriel, Nir

AU - Sayer, Gabriel

AU - Sims, Daniel

AU - Zahner, Doris

AU - Farr, Maryjane

AU - Mancini, Donna

AU - Jorde, Ulrich P.

PY - 2010/3

Y1 - 2010/3

N2 - Coronary vascular reserve is impaired during acute cellular rejection of the orthotopically transplanted heart, but changes in the peripheral vasculature during rejection have not been well described. To investigate whether peripheral vascular compensatory mechanisms are preserved after orthotopic heart transplantation (OHT), we longitudinally observed systemic vascular resistance (SVR) and cardiac output (CO) during acute cellular rejection. CO decreased during high-grade acute cellular rejection, and maintenance of mean arterial pressure was achieved by increases in SVR, and these changes did not return to baseline until several months after histologic resolution of rejection.

AB - Coronary vascular reserve is impaired during acute cellular rejection of the orthotopically transplanted heart, but changes in the peripheral vasculature during rejection have not been well described. To investigate whether peripheral vascular compensatory mechanisms are preserved after orthotopic heart transplantation (OHT), we longitudinally observed systemic vascular resistance (SVR) and cardiac output (CO) during acute cellular rejection. CO decreased during high-grade acute cellular rejection, and maintenance of mean arterial pressure was achieved by increases in SVR, and these changes did not return to baseline until several months after histologic resolution of rejection.

KW - heart transplantation

KW - hemodynamics

KW - rejection

KW - systemic vascular resistance

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AN - SCOPUS:77349087799

SN - 1053-2498

VL - 29

SP - 382

EP - 384

JO - Journal of Heart and Lung Transplantation

JF - Journal of Heart and Lung Transplantation

IS - 3

ER -

Alteration in systemic vascular resistance and cardiac output during acute cellular rejection and recovery in heart transplant recipients

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Keywords

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