ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway

Keyphrases

• Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) 100%
• SQSTM1 100%
• Amyotrophic Lateral Sclerosis 100%
• Selective Autophagy 100%
• Oxidative Stress Pathway 100%
• Frontotemporal Lobar Degeneration 100%
• Anti-oxidative Stress 100%
• NFE2L2 100%
• Kelch-like ECH-associated Protein 1 (Keap1) 40%
• TBK1 40%
• Phosphorylation 30%
• Autophagy 30%
• TAR DNA-binding Protein 43 (TDP-43) 30%
• ULK1 30%
• Autophagy Receptor 30%
• Cargo 20%
• TARDBP 20%
• GSTM1 20%
• Heme oxygenase-1 (HO-1) 20%
• Neurotoxicity 20%
• Superoxide Dismutase 1 (SOD1) 20%
• NBR1 20%
• Oxidative Stress 10%
• Neurodegenerative Diseases 10%
• Binding Protein 10%
• Autophagy Pathway 10%
• Co-immunoprecipitation (co-IP) 10%
• Ubiquitin 10%
• Disease-causing mutations 10%
• Pathogenic Mechanism 10%
• Digestion 10%
• Autophagosome 10%
• Macroautophagy 10%
• Associated Proteins 10%
• Proteotoxic Stress 10%
• Dendrite Morphology 10%
• SH3 Domain 10%
• Dehydrogenase 10%
• Oxidative Stress Response 10%
• Quinones 10%
• Protein Aggregates 10%
• Target Gene Expression 10%
• Impaired Autophagy 10%
• GTPase-activating Protein 10%
• Catabolic Pathway 10%
• Microtubule-associated Protein 1 Light Chain 3 10%
• MAP1LC3B 10%
• Serum Starvation 10%
• NAD(P) 10%
• Proteostasis 10%
• G3BP1 10%
• Kelch-like 10%
• Cargo Binding 10%
• Stress Granule Formation 10%
• Maltose-binding Protein 10%
• UBA Domain 10%
• NAD(P)H:Quinone Oxidoreductase 1 (NQO1) 10%
• Interaction Region 10%
• Serine/threonine Kinase 10%
• Sequestosome 1 10%
• TANK Binding Kinase 1 10%
• Autophagy Degradation 10%
• Autophagy Cargo Receptors 10%

Biochemistry, Genetics and Molecular Biology

• Oxidative Stress 100%
• Autophagy 100%
• Selective Autophagy 100%
• NFE2L2 100%
• Kinase 66%
• Phosphotransferase 66%
• KEAP1 66%
• Synapsin I 50%
• Transcription Factor Nrf2 50%
• phosphorylation 50%
• Autophagy Receptor 50%
• ULK1 33%
• Transactive Response Dna Binding Protein-43 33%
• TARDBP 33%
• NBR1 33%
• Superoxide Dismutase 16%
• Binding Protein 16%
• Gene Expression 16%
• Wild Type 16%
• Microtubule-Associated Protein 16%
• Autophagosome 16%
• Macroautophagy 16%
• Light Chain 16%
• Ubiquitin 16%
• Immunoprecipitation 16%
• Heme Oxygenase 16%
• SH3 Domain 16%
• TANK-binding Kinase 1 16%
• GTPase-activating Protein 16%
• Sequestosome 1 16%
• Protein Homeostasis 16%
• SOD1 16%
• TAR DNA Binding Protein 16%
• Stress Granule 16%
• NAD(P)H Dehydrogenase (Quinone 1) 16%
• Maltose-Binding Protein 16%
• Glutathione S-Transferase Mu 1 16%
• Serine 16%
• Threonine 16%
• Dendrite 16%