Alpha2-adrenergic receptor function in patients with unipolar and bipolar affective disorders

Marian S. Kafka; John I. Nurnberger; Larry Siever; Steven Targum; Thomas W. Uhde; Elliot S. Gershon

doi:10.1016/0165-0327(86)90038-8

Alpha₂-adrenergic receptor function in patients with unipolar and bipolar affective disorders

Marian S. Kafka, John I. Nurnberger, Larry Siever, Steven Targum, Thomas W. Uhde, Elliot S. Gershon

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Alpha₂-adrenergic receptor function was measured in platelets from unipolar (UP) depressed, bipolar (BP) depressed, and bipolar euthymic patients and normal control subjects. Only the platelets from UP depressed patients were different from control in having an increased number of α₂-receptors, a decreased percent norepinephrine inhibition of prostaglandin E₁ (PGE₁)-stimulated cyclic AMP (cAMP) production, and a decrease in PGE₁ stimulation of cAMP production. Platelets from BP patients, depressed or euthymic, were not significantly different from control subjects. These preliminary data suggest that α₂-adrenergic receptor function and PGE₁ stimulation of cAMP production are diminished in UP patients.

Original language	English
Pages (from-to)	163-169
Number of pages	7
Journal	Journal of Affective Disorders
Volume	10
Issue number	2
DOIs	https://doi.org/10.1016/0165-0327(86)90038-8
State	Published - 1986

Keywords

Affective disorders
Alpha-adrenergic receptor
Cyclic AMP
Platelet

Access to Document

10.1016/0165-0327(86)90038-8

Cite this

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title = "Alpha2-adrenergic receptor function in patients with unipolar and bipolar affective disorders",

abstract = "Alpha2-adrenergic receptor function was measured in platelets from unipolar (UP) depressed, bipolar (BP) depressed, and bipolar euthymic patients and normal control subjects. Only the platelets from UP depressed patients were different from control in having an increased number of α2-receptors, a decreased percent norepinephrine inhibition of prostaglandin E1 (PGE1)-stimulated cyclic AMP (cAMP) production, and a decrease in PGE1 stimulation of cAMP production. Platelets from BP patients, depressed or euthymic, were not significantly different from control subjects. These preliminary data suggest that α2-adrenergic receptor function and PGE1 stimulation of cAMP production are diminished in UP patients.",

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T1 - Alpha2-adrenergic receptor function in patients with unipolar and bipolar affective disorders

AU - Kafka, Marian S.

AU - Nurnberger, John I.

AU - Siever, Larry

AU - Targum, Steven

AU - Uhde, Thomas W.

AU - Gershon, Elliot S.

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AB - Alpha2-adrenergic receptor function was measured in platelets from unipolar (UP) depressed, bipolar (BP) depressed, and bipolar euthymic patients and normal control subjects. Only the platelets from UP depressed patients were different from control in having an increased number of α2-receptors, a decreased percent norepinephrine inhibition of prostaglandin E1 (PGE1)-stimulated cyclic AMP (cAMP) production, and a decrease in PGE1 stimulation of cAMP production. Platelets from BP patients, depressed or euthymic, were not significantly different from control subjects. These preliminary data suggest that α2-adrenergic receptor function and PGE1 stimulation of cAMP production are diminished in UP patients.

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