TY - JOUR
T1 - Alopecia Areata
T2 - A Complex Cytokine Driven Disease
AU - Song, Teresa
AU - Guttman-Yassky, Emma
N1 - Publisher Copyright:
© 2020 The Authors
PY - 2020/11
Y1 - 2020/11
N2 - Alopecia areata (AA) has been recently shown to also include T-helper cell type 2/IL-23 activation, in addition to T-helper cell type 1/IFN-skewing. The success of Jak inhibition together with IL-4Rα antagonism and limited response to IL-17A and PDE4 (protein) inhibition in AA are increasing our understanding of the complex immune interplay in AA. Trials testing targeted therapeutics are needed to further elucidate the pathogenic contribution of various cytokines.
AB - Alopecia areata (AA) has been recently shown to also include T-helper cell type 2/IL-23 activation, in addition to T-helper cell type 1/IFN-skewing. The success of Jak inhibition together with IL-4Rα antagonism and limited response to IL-17A and PDE4 (protein) inhibition in AA are increasing our understanding of the complex immune interplay in AA. Trials testing targeted therapeutics are needed to further elucidate the pathogenic contribution of various cytokines.
UR - http://www.scopus.com/inward/record.url?scp=85092535601&partnerID=8YFLogxK
U2 - 10.1016/j.jisp.2020.04.007
DO - 10.1016/j.jisp.2020.04.007
M3 - Comment/debate
C2 - 33099386
AN - SCOPUS:85092535601
SN - 1087-0024
VL - 20
SP - S55-S57
JO - Journal of Investigative Dermatology Symposium Proceedings
JF - Journal of Investigative Dermatology Symposium Proceedings
IS - 1
ER -