Allodynia and neuronal plasticity

Neuropathic pain is typically acccompanied by a constelation of signs and symptoms that gives to this condition a very distinct presentation. Allodynia - pain sensation induced by non-noxious stimuli, along with hyperalgesia - an exagerated response to noxious stimuli, are common findings in neuropathic pain, and are frequently accompanied by dysesthesias, paresthesias, after-sensations, and less frequently by changes in coloration and temperature of the affected area. Both hyperalgesia and allodynia are of special interest becuase they seem to be sensory expressions of very complex underlying phenomena. This article discusses neural mechanisms in the development and maintenance of allodynia, and the role of peripheral- and central sensitization in sensory disturbances present in neuropathic pain.