Allergen component testing for food allergy: Ready for prime time?

Jacob D. Kattan, Julie Wang

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Food allergies can cause life-threatening reactions and greatly influence quality of life. Accurate diagnosis of food allergies is important to avoid serious allergic reactions and prevent unnecessary dietary restrictions, but can be difficult. Skin prick testing (SPT) and serum food-specific IgE (sIgE) levels are extremely sensitive testing options, but positive test results to tolerated foods are not uncommon. Allergen component-resolved diagnostics (CRD) have the potential to provide a more accurate assessment in diagnosing food allergies. Recently, a number of studies have demonstrated that CRD may improve the specificity of allergy testing to a variety of foods including peanut, milk, and egg. While it may be a helpful adjunct to current diagnostic testing, CRD is not ready to replace existing methods of allergy testing, as it not as sensitive, is not widely available, and evaluations of component testing for a number of major food allergens are lacking.

Original languageEnglish
Pages (from-to)58-63
Number of pages6
JournalCurrent Allergy and Asthma Reports
Issue number1
StatePublished - Feb 2013


  • Component-resolved diagnostics
  • Diagnosis
  • Egg allergy
  • Food allergy
  • Food-specific IgE
  • Hazelnut allergy
  • Microarray
  • Milk allergy
  • Oral food challenge
  • Peanut allergy
  • Sensitivity
  • Shrimp allergy
  • Skin prick testing
  • Specificity


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