Allele-specific down-regulation of MHC class I antigens in Burkitt lymphoma lines

Maria G. Masucic; Nico J. Stam; Sigurbjörg Torsteinsdottir; Jaques J. Neefjes; George Klein; Hidde L. Ploegh

doi:10.1016/0008-8749(89)90207-4

Allele-specific down-regulation of MHC class I antigens in Burkitt lymphoma lines

Maria G. Masucic, Nico J. Stam, Sigurbjörg Torsteinsdottir, Jaques J. Neefjes, George Klein, Hidde L. Ploegh

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

We have reported that Burkitt lymphomas (BL) that arise in HLA-A11 positive individuals are resistant to lysis by HLA-A11-specific and HLA-A11-restricted CTLs (10, 11). Here we show that this phenomenon can be explained by a selective loss of the HLA-A11 polypeptide. The HLA-A11 negative phenotype is due to a regulatory phenomenon, rather than a structural defect, as proven by the ability to rescue expression of HLA-A11 in in vitro Epstein-Barr virus (EBV)-converted sublines of EBV negative BLs.

Original language	English
Pages (from-to)	396-400
Number of pages	5
Journal	Cellular Immunology
Volume	120
Issue number	2
DOIs	https://doi.org/10.1016/0008-8749(89)90207-4
State	Published - May 1989
Externally published	Yes

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@article{65c458c9887e478e8f8af30dfffd0487,

title = "Allele-specific down-regulation of MHC class I antigens in Burkitt lymphoma lines",

abstract = "We have reported that Burkitt lymphomas (BL) that arise in HLA-A11 positive individuals are resistant to lysis by HLA-A11-specific and HLA-A11-restricted CTLs (10, 11). Here we show that this phenomenon can be explained by a selective loss of the HLA-A11 polypeptide. The HLA-A11 negative phenotype is due to a regulatory phenomenon, rather than a structural defect, as proven by the ability to rescue expression of HLA-A11 in in vitro Epstein-Barr virus (EBV)-converted sublines of EBV negative BLs.",

author = "Masucic, {Maria G.} and Stam, {Nico J.} and Sigurbj{\"o}rg Torsteinsdottir and Neefjes, {Jaques J.} and George Klein and Ploegh, {Hidde L.}",

note = "Funding Information: This researchw ass upportedb y NIH Grant 5R01 CA 3264-06t,h e SwedishC ancerS ociety,t heSwedish Medical Association,t he DeutscheF orschungsgemeinscha(Sftc hwerpunktsprogrammIm munogenetik), and the Queen Wilhelmina Foundation (NKI 85/10). M.G.M. was supportedb y ICRETT travel fellowship.",

year = "1989",

month = may,

doi = "10.1016/0008-8749(89)90207-4",

language = "English",

volume = "120",

pages = "396--400",

journal = "Cellular Immunology",

issn = "0008-8749",

publisher = "Academic Press Inc.",

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T1 - Allele-specific down-regulation of MHC class I antigens in Burkitt lymphoma lines

AU - Masucic, Maria G.

AU - Stam, Nico J.

AU - Torsteinsdottir, Sigurbjörg

AU - Neefjes, Jaques J.

AU - Klein, George

AU - Ploegh, Hidde L.

N1 - Funding Information: This researchw ass upportedb y NIH Grant 5R01 CA 3264-06t,h e SwedishC ancerS ociety,t heSwedish Medical Association,t he DeutscheF orschungsgemeinscha(Sftc hwerpunktsprogrammIm munogenetik), and the Queen Wilhelmina Foundation (NKI 85/10). M.G.M. was supportedb y ICRETT travel fellowship.

PY - 1989/5

Y1 - 1989/5

N2 - We have reported that Burkitt lymphomas (BL) that arise in HLA-A11 positive individuals are resistant to lysis by HLA-A11-specific and HLA-A11-restricted CTLs (10, 11). Here we show that this phenomenon can be explained by a selective loss of the HLA-A11 polypeptide. The HLA-A11 negative phenotype is due to a regulatory phenomenon, rather than a structural defect, as proven by the ability to rescue expression of HLA-A11 in in vitro Epstein-Barr virus (EBV)-converted sublines of EBV negative BLs.

AB - We have reported that Burkitt lymphomas (BL) that arise in HLA-A11 positive individuals are resistant to lysis by HLA-A11-specific and HLA-A11-restricted CTLs (10, 11). Here we show that this phenomenon can be explained by a selective loss of the HLA-A11 polypeptide. The HLA-A11 negative phenotype is due to a regulatory phenomenon, rather than a structural defect, as proven by the ability to rescue expression of HLA-A11 in in vitro Epstein-Barr virus (EBV)-converted sublines of EBV negative BLs.

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U2 - 10.1016/0008-8749(89)90207-4

DO - 10.1016/0008-8749(89)90207-4

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SN - 0008-8749

VL - 120

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EP - 400

JO - Cellular Immunology

JF - Cellular Immunology

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ER -

Allele-specific down-regulation of MHC class I antigens in Burkitt lymphoma lines

Abstract

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