All Roads Lead to the miRNome: miRNAs Have a Central Role in the Molecular Pathophysiology of Psychiatric Disorders

Richard M. O'Connor, Anand Gururajan, Timothy G. Dinan, Paul J. Kenny, John F. Cryan

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations

Abstract

Current treatment strategies for psychiatric disorders remain inadequate. Impeding development of novel therapeutics is our incomplete knowledge of the molecular pathophysiology underlying these disorders. Changes to miRNA function and expression are increasingly being associated with pathological behavioral states. Furthermore, the prospect of using of miRNA expression profiles (the miRNome) as objective psychiatric diagnosis tools is gaining traction. In this review, we focus on recent findings surrounding the link between miRNA function and psychiatric disorders, and outline some of the key challenges that will need to be overcome if the therapeutic potential of these molecular effectors is to be fully realized.

Original languageEnglish
Pages (from-to)1029-1044
Number of pages16
JournalTrends in Pharmacological Sciences
Volume37
Issue number12
DOIs
StatePublished - 1 Dec 2016

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