Alkalosis from Chloride-Deficient Neo-Mull-Soy

Allen M. Kaufman, Fernand Mac-Moune, Thomas Kahn

Research output: Contribution to journalLetterpeer-review


To the Editor: In a letter in the September 13 issue, it was suggested that a diet containing little chloride and a moderately large amount of citrate provoked hypokalemic hypochloremic metabolic alkalosis in infants.1 We have studied rats maintained for two to three weeks on a low-chloride diet containing a normal amount of sodium and a moderately increased quantity of citrate. These rats grew normally, maintained a normal hematocrit, and had no abnormalities in serum electrolytes, pH or partial pressure of serum carbon dioxide. When these rats were chloride-depleted by the administration of furosemide, net acid excretion increased and metabolic. No extract is available for articles shorter than 400 words.

Original languageEnglish
Pages (from-to)1449
Number of pages1
JournalNew England Journal of Medicine
Issue number26
StatePublished - 27 Dec 1979


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