TY - JOUR
T1 - Alkaline phosphatase phenotypes in tumour and non-tumour cell lines
T2 - Not an invariable marker for neoplastic transformation
AU - Wilson, P. D.
AU - Benham, F.
AU - Franks, L. M.
PY - 1977/5
Y1 - 1977/5
N2 - The cytochemical localisation and presumed isoenzyme type (based on selective inhibition experiments) of alkaline phosphatase in 5 cell lines derived from normal human, rat, mouse and hamster tissues, 6 human lymphoblastoid lines and 6 human and mouse tumour-derived cell lines are described. Enzyme activity varied between the cell lines. An isoenzyme inhibited by L-phenylalanine was present in 3 normal lines, 3 lymphoblastoid lines and 2 tumour lines. The presence of this isoenzyme cannot be used as a marker of neoplastic transformation.
AB - The cytochemical localisation and presumed isoenzyme type (based on selective inhibition experiments) of alkaline phosphatase in 5 cell lines derived from normal human, rat, mouse and hamster tissues, 6 human lymphoblastoid lines and 6 human and mouse tumour-derived cell lines are described. Enzyme activity varied between the cell lines. An isoenzyme inhibited by L-phenylalanine was present in 3 normal lines, 3 lymphoblastoid lines and 2 tumour lines. The presence of this isoenzyme cannot be used as a marker of neoplastic transformation.
UR - http://www.scopus.com/inward/record.url?scp=0017490279&partnerID=8YFLogxK
U2 - 10.1016/0309-1651(77)90047-9
DO - 10.1016/0309-1651(77)90047-9
M3 - Article
C2 - 608181
AN - SCOPUS:0017490279
SN - 0309-1651
VL - 1
SP - 229
EP - 238
JO - Cell Biology International Reports
JF - Cell Biology International Reports
IS - 3
ER -