Alkaline phosphatase activity in cultured skin fibroblasts from fibrodysplasia ossificans progressiva

N. G. Beratis, S. Kaffe, A. M. Aron, K. Hirschhorn

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Alkaline phosphatase activity in 4 strains of cultured skin fibroblasts obtained from a patient with fibrodysplasia ossificans progressiva was at the low normal range. The enzyme activity in normal fibroblasts significantly increased at late confluency. It appears that the high levels of alkaline phosphatase activity reported in biopsies of lesions are not genetically determined but are secondary events of local tissue reaction.

Original languageEnglish
Pages (from-to)307-309
Number of pages3
JournalJournal of Medical Genetics
Volume13
Issue number4
DOIs
StatePublished - 1976
Externally publishedYes

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