ALK-positive anaplastic large cell lymphoma in a patient with chronic lymphocytic leukemia

Liu Ting Liu, He Mai He, Diane L. Carlson, Cyrus Hedvat, Julie Teruya-Feldstein

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


This article reports the case of a 59-year-old patient with an 8-year history of chronic lymphocytic leukemia (CLL), prostate carcinoma, and squamous cell carcinoma who developed an ALK-positive anaplastic large cell lymphoma (ALCL). Lymph node and bone marrow biopsies showed 2 distinct morphologic populations: (a) the CLL component showing a diffuse monomorphous infiltrate of small lymphocytes with the typical immunophenotype showing positive CD20, CD5, CD23, and κ light chain restriction and (b) the ALCL component showing large anaplastic pleomorphic cells positive for CD30, CD45, ALK, CD45Ro, CD4, and vimentin. Polymerase chain reaction performed on the lymph node for immunoglobulin heavy chain and T-cell receptor γ and β showed gene rearrangements after macrodissection of morphologically distinct populations, indicating confirmed genetically distinct populations. Despite intensive chemotherapy, the patient died. This case represents the rare occurrence of an ALK-positive ALCL developing in a patient with CLL.

Original languageEnglish
Pages (from-to)424-428
Number of pages5
JournalInternational Journal of Surgical Pathology
Issue number5
StatePublished - Oct 2010
Externally publishedYes


  • anaplastic large cell lymphoma
  • chronic lymphocytic leukemia
  • composite
  • synchronous lymphoma


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