Alien hand syndrome: Interhemispheric motor disconnection due to a lesion in the midbody of the corpus callosum

D. H. Geschwind, M. Iacoboni, M. S. Mega, D. W. Zaidel, T. Cloughesy, E. Zaidel

Research output: Contribution to journalArticlepeer-review

85 Scopus citations

Abstract

Article abstract-The neuroanatomic substrate of the alien hand syndrome has remained controversial due to the noncircumscribed nature of cerebral injuries present in most cases. There have been few cases studied in which damage was restricted to portions of the body of the callosum, and most of those involved surgical callosotomy for tumors or epilepsy. We report the case of a woman with a transient alien hand syndrome caused by a stroke limited to the middle and posterior portions of the body of the corpus callosum. This case provides supportive evidence for damage to the midbody of the corpus callosum as the anatomic basis of nondominant alien hand syndrome and conforms to a model of interhemispheric motor disconnection as the essential component of this unusual behavioral syndrome. This disconnection can occur with injuries involving interhemispheric premotor and motor fibers traveling in the midportion of the callosum in individuals with left hemisphere dominance for motor activities.

Original languageEnglish
Pages (from-to)802-808
Number of pages7
JournalNeurology
Volume45
Issue number4
DOIs
StatePublished - Apr 1995
Externally publishedYes

Fingerprint

Dive into the research topics of 'Alien hand syndrome: Interhemispheric motor disconnection due to a lesion in the midbody of the corpus callosum'. Together they form a unique fingerprint.

Cite this