Abstract
This article describes the pathways and factors that modulate blood alcohol levels and metabolism and describes how the body disposes of alcohol. The various factors that play a role in the distribution of alcohol in the body, influence the absorption of alcohol, and contribute to first-pass metabolism of alcohol are described. Most alcohol is oxidized in the liver, and general principles and overall mechanisms for alcohol oxidation are summarized. The kinetics of alcohol elimination in-vivo and the various genetic and environmental factors that can modify the rate of alcohol metabolism are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 667-685 |
| Number of pages | 19 |
| Journal | Clinics in Liver Disease |
| Volume | 16 |
| Issue number | 4 |
| DOIs | |
| State | Published - Nov 2012 |
Keywords
- Acetaldehyde metabolism
- Alcohol absorption
- Alcohol dehydrogenase
- Cytochrome P4502E1
- Distribution and elimination
- Hepatic redox state
- Isoforms of alcohol dehydrogenase
- Metabolic adaptation to alcohol