Alanine stimulation of the pancreatic α and β cell in the neonatal lamb

R. H. Fiser, D. Phelps, P. Williams, M. A. Sperling, W. O, D. A. Fisher

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Alanine infusion in the newborn sheep produced a significant increase in plasma immunoreactive insulin concentrations without a change in plasma glucose or glucagon levels. In contrast, a brisk response of glucagon and glucose were seen in adult sheep after similar infusions. These data suggest that in newborn lambs pancreatic β cell responsiveness matures earlier than the α cell response.

Original languageEnglish
Pages (from-to)171-175
Number of pages5
JournalNeonatology
Volume25
Issue number3-4
StatePublished - 1974

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