Airway function in chronic pulmonary sarcoidosis with fibrosis

A. Miller, A. S. Teirstein, I. Jackler, M. Chuang, L. E. Siltzbach

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Sixteen patients with pulmonary fibrosis due to chronic sarcoidosis were studied for evidence of impaired airway function using conventional spirometric indices of air flow, functional residual capacity measured by helium dilution, single breath nitrogen wash out, and maximum expiratory flow volume curves. The maximal midexpiratory flow was decreased, but an analysis of flow volume relationships was required to determine whether the diminished flow was secondary to reduced volume or to airway obstruction. In 12 of the 16 patients, reduction in air flow exceeded reduction in lung volume, a pattern consistent with airway obstruction. The other 4 patients had a restrictive pattern in which loss of volume exceeded loss of flow. No patient had hyperinflation. Distribution of inspired air was impaired in 10 of the 12 patients with obstruction and in all 3 of those with restriction who were tested. The airway obstruction and impaired distribution of ventilation, which were found in most patients with chronic pulmonary sarcoidosis, are consistent with structural changes in the airways that accompany pulmonary fibrosis.

Original languageEnglish
Pages (from-to)179-189
Number of pages11
JournalAmerican Journal of Respiratory and Critical Care Medicine
Issue number2
StatePublished - 1974
Externally publishedYes


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