TY - JOUR
T1 - Air Travel Is Associated with Intracontinental Spread of Dengue Virus Serotypes 1-3 in Brazil
AU - Nunes, Marcio R.T.
AU - Palacios, Gustavo
AU - Faria, Nuno Rodrigues
AU - Sousa, Edivaldo Costa
AU - Pantoja, Jamilla A.
AU - Rodrigues, Sueli G.
AU - Carvalho, Valéria L.
AU - Medeiros, Daniele B.A.
AU - Savji, Nazir
AU - Baele, Guy
AU - Suchard, Marc A.
AU - Lemey, Philippe
AU - Vasconcelos, Pedro F.C.
AU - Lipkin, W. Ian
PY - 2014/4
Y1 - 2014/4
N2 - Dengue virus and its four serotypes (DENV-1 to DENV-4) infect 390 million people and are implicated in at least 25,000 deaths annually, with the largest disease burden in tropical and subtropical regions. We investigated the spatial dynamics of DENV-1, DENV-2 and DENV-3 in Brazil by applying a statistical framework to complete genome sequences. For all three serotypes, we estimated that the introduction of new lineages occurred within 7 to 10-year intervals. New lineages were most likely to be imported from the Caribbean region to the North and Northeast regions of Brazil, and then to disperse at a rate of approximately 0.5 km/day. Joint statistical analysis of evolutionary, epidemiological and ecological data indicates that aerial transportation of humans and/or vector mosquitoes, rather than Aedes aegypti infestation rates or geographical distances, determine dengue virus spread in Brazil.
AB - Dengue virus and its four serotypes (DENV-1 to DENV-4) infect 390 million people and are implicated in at least 25,000 deaths annually, with the largest disease burden in tropical and subtropical regions. We investigated the spatial dynamics of DENV-1, DENV-2 and DENV-3 in Brazil by applying a statistical framework to complete genome sequences. For all three serotypes, we estimated that the introduction of new lineages occurred within 7 to 10-year intervals. New lineages were most likely to be imported from the Caribbean region to the North and Northeast regions of Brazil, and then to disperse at a rate of approximately 0.5 km/day. Joint statistical analysis of evolutionary, epidemiological and ecological data indicates that aerial transportation of humans and/or vector mosquitoes, rather than Aedes aegypti infestation rates or geographical distances, determine dengue virus spread in Brazil.
UR - http://www.scopus.com/inward/record.url?scp=84901279781&partnerID=8YFLogxK
U2 - 10.1371/journal.pntd.0002769
DO - 10.1371/journal.pntd.0002769
M3 - Article
C2 - 24743730
AN - SCOPUS:84901279781
SN - 1935-2727
VL - 8
JO - PLoS Neglected Tropical Diseases
JF - PLoS Neglected Tropical Diseases
IS - 4
M1 - e2769
ER -