TY - JOUR
T1 - Air pollution, urgent asthma medical visits and the modifying effect of neighborhood asthma prevalence
AU - Lovinsky-Desir, Stephanie
AU - Acosta, Luis M.
AU - Rundle, Andrew G.
AU - Miller, Rachel L.
AU - Goldstein, Inge F.
AU - Jacobson, Judith S.
AU - Chillrud, Steven N.
AU - Perzanowski, Matthew S.
N1 - Publisher Copyright:
© 2018, International Pediatric Research Foundation, Inc.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Background: Social and environmental stressors may modify associations between environmental pollutants and asthma symptoms. We examined if neighborhood asthma prevalence (higher: HAPN vs. lower: LAPN), a surrogate for underlying risk factors for asthma, modified the relationship between pollutants and urgent asthma visits. Methods: Through zip code, home addresses were linked to New York City Community Air Survey’s land use regression model for street-level, annual average nitrogen dioxide (NO 2 ), particulate matter (PM 2.5 ), elemental carbon (EC), summer average ozone (O 3 ), winter average sulfur dioxide (SO 2 ) concentrations. Poisson regression models were fit to estimate the association (prevalence ratio, PR) between pollutant exposures and seeking urgent asthma care. Results: All pollutants, except O 3 were higher in HAPN than LAPN (P < 0.01). Neighborhood asthma prevalence modified the relationship between pollutants and urgent asthma (P-interaction < 0.01, for NO 2 and SO 3 ). Associations between pollutants and urgent asthma were observed only in LAPN (NO 2 : PR = 1.38, P = 0.01; SO 3 : PR = 1.85, P = 0.04). No association was observed between pollutants and urgent asthma among children in HAPN (P > 0.05). Conclusions: Relationships between modeled street-level pollutants and urgent asthma were stronger in LAPN compared to HAPN. Social stressors that may be more prevalent in HAPN than LAPN, could play a greater role in asthma exacerbations in HAPN vs. pollutant exposure alone.
AB - Background: Social and environmental stressors may modify associations between environmental pollutants and asthma symptoms. We examined if neighborhood asthma prevalence (higher: HAPN vs. lower: LAPN), a surrogate for underlying risk factors for asthma, modified the relationship between pollutants and urgent asthma visits. Methods: Through zip code, home addresses were linked to New York City Community Air Survey’s land use regression model for street-level, annual average nitrogen dioxide (NO 2 ), particulate matter (PM 2.5 ), elemental carbon (EC), summer average ozone (O 3 ), winter average sulfur dioxide (SO 2 ) concentrations. Poisson regression models were fit to estimate the association (prevalence ratio, PR) between pollutant exposures and seeking urgent asthma care. Results: All pollutants, except O 3 were higher in HAPN than LAPN (P < 0.01). Neighborhood asthma prevalence modified the relationship between pollutants and urgent asthma (P-interaction < 0.01, for NO 2 and SO 3 ). Associations between pollutants and urgent asthma were observed only in LAPN (NO 2 : PR = 1.38, P = 0.01; SO 3 : PR = 1.85, P = 0.04). No association was observed between pollutants and urgent asthma among children in HAPN (P > 0.05). Conclusions: Relationships between modeled street-level pollutants and urgent asthma were stronger in LAPN compared to HAPN. Social stressors that may be more prevalent in HAPN than LAPN, could play a greater role in asthma exacerbations in HAPN vs. pollutant exposure alone.
UR - http://www.scopus.com/inward/record.url?scp=85055588851&partnerID=8YFLogxK
U2 - 10.1038/s41390-018-0189-3
DO - 10.1038/s41390-018-0189-3
M3 - Article
C2 - 30337671
AN - SCOPUS:85055588851
SN - 0031-3998
VL - 85
SP - 36
EP - 42
JO - Pediatric Research
JF - Pediatric Research
IS - 1
ER -