Air Pollution and Lung Cancer: Contributions of Extracellular Vesicles as Pathogenic Mechanisms and Clinical Utility

Jonathan González-Ruíz, Andrea A.Baccarelli, David Cantu-de-Leon, Diddier Prada

Research output: Contribution to journalReview articlepeer-review

Abstract

Purpose of Review: This review addresses the pressing issue of air pollution’s threat to human health, focusing on its connection to non-small cell lung cancer (NSCLC) development. The aim is to explore the role of extracellular vesicles (EVs) as potential pathogenic mechanisms in lung cancer, including NSCLC, induced by air pollutants. Recent Findings: Recent research highlights EVs as vital mediators of intercellular communication and key contributors to cancer progression. Notably, this review emphasizes the cargo of EVs released by both cancerous and non-cancerous lung cells, shedding light on their potential role in promoting various aspects of tumor development. Summary: The review underscores the importance of comprehending the intricate interplay between air pollution, biological damage mechanisms, and EV-mediated communication during NSCLC development. Major takeaways emphasize the significance of this understanding in addressing air pollution-related lung cancer. Future research avenues are also highlighted, aiming to enhance the applicability of EVs for diagnosis and targeted therapies, ultimately mitigating the inevitable impact of air pollution on NSCLC development and treatment.

Original languageEnglish
Pages (from-to)478-489
Number of pages12
JournalCurrent Environmental Health Reports
Volume10
Issue number4
DOIs
StatePublished - Dec 2023

Keywords

  • Air pollution
  • Biomarkers
  • Extracellular vesicles
  • Lung cancer
  • Therapeutic targets

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