AIDS and AIDS-treatment neuropathies

Derek Williams, Anthony Geraci, David M. Simpson

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

AIDS and AIDS-treatment neuropathies are common in individuals infected with HIV. As patients live longer due to improved antiretroviral therapies, the impact of painful neuropathy on patients’ lives may increase. Several antiretroviral medications are known to cause toxic neuropathy in patients with AIDS, but this may be outweighed by the beneficial effects of viral suppression. Current theories on the pathogenesis of AIDS neuropathies include mitochondrial toxicity secondary to γ-DNA polymerase inhibition and subsequent abnormal mitochondrial DNA synthesis. Treatment of AIDS neuropathies is directed toward relief of symptoms; however, new evidence suggests that aggressive antiretroviral therapy may also be effective.

Original languageEnglish
Pages (from-to)125-130
Number of pages6
JournalCurrent Pain and Headache Reports
Volume6
Issue number2
DOIs
StatePublished - Apr 2002
Externally publishedYes

Keywords

  • Lamotrigine
  • Mitochondrial Toxicity
  • Nerve Conduction Study
  • Neuropathy
  • Stavudine

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