AIDS and AIDS-treatment neuropathies.

D. Williams, A. Geraci, D. M. Simpson

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

AIDS and AIDS-treatment neuropathies are common in individuals infected with HIV. As patients live longer due to improved antiretroviral therapies, the impact of painful neuropathy on patients' lives may increase. Several antiretroviral medications are known to cause toxic neuropathy in AIDS patients; but this may be outweighed by the beneficial effects of viral suppression. Current theories on the pathogenesis of AIDS neuropathies include mitochondrial toxicity secondary to gamma-DNA polymerase inhibition and subsequent abnormal mitochondrial DNA synthesis. Treatment of AIDS neuropathies is directed toward relief of symptoms, however, new evidence suggests that aggressive antiretroviral therapy may also be effective.

Original languageEnglish
Pages (from-to)533-538
Number of pages6
JournalCurrent Neurology and Neuroscience Reports
Volume1
Issue number6
DOIs
StatePublished - Nov 2001

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