TY - JOUR
T1 - AHTPDB
T2 - A comprehensive platform for analysis and presentation of antihypertensive peptides
AU - Kumar, Ravi
AU - Chaudhary, Kumardeep
AU - Sharma, Minakshi
AU - Nagpal, Gandharva
AU - Chauhan, Jagat Singh
AU - Singh, Sandeep
AU - Gautam, Ankur
AU - Raghava, Gajendra P.S.
N1 - Publisher Copyright:
© The Author(s) 2014.
PY - 2015/1/28
Y1 - 2015/1/28
N2 - AHTPDB (http://crdd.osdd.net/raghava/ahtpdb/) is a manually curated database of experimentally validated antihypertensive peptides. Information pertaining to peptides with antihypertensive activity was collected from research articles and from various peptide repositories. These peptides were derived from 35 major sources that include milk, egg, fish, pork, chicken, soybean, etc. In AHTPDB, most of the peptides belong to a family of angiotensin-I converting enzyme inhibiting peptides. The current release of AHTPDB contains 5978 peptide entries among which 1694 are unique peptides. Each entry provides detailed information about a peptide like sequence, inhibitory concentration (IC50), toxicity/bitterness value, source, length, molecular mass and information related to purification of peptides. In addition, the database provides structural information of these peptides that includes predicted tertiary and secondary structures. A user-friendly web interface with various tools has been developed to retrieve and analyse the data. It is anticipated that AHTPDB will be a useful and unique resource for the researchers working in the field of antihypertensive peptides.
AB - AHTPDB (http://crdd.osdd.net/raghava/ahtpdb/) is a manually curated database of experimentally validated antihypertensive peptides. Information pertaining to peptides with antihypertensive activity was collected from research articles and from various peptide repositories. These peptides were derived from 35 major sources that include milk, egg, fish, pork, chicken, soybean, etc. In AHTPDB, most of the peptides belong to a family of angiotensin-I converting enzyme inhibiting peptides. The current release of AHTPDB contains 5978 peptide entries among which 1694 are unique peptides. Each entry provides detailed information about a peptide like sequence, inhibitory concentration (IC50), toxicity/bitterness value, source, length, molecular mass and information related to purification of peptides. In addition, the database provides structural information of these peptides that includes predicted tertiary and secondary structures. A user-friendly web interface with various tools has been developed to retrieve and analyse the data. It is anticipated that AHTPDB will be a useful and unique resource for the researchers working in the field of antihypertensive peptides.
UR - http://www.scopus.com/inward/record.url?scp=84941124146&partnerID=8YFLogxK
U2 - 10.1093/nar/gku1141
DO - 10.1093/nar/gku1141
M3 - Article
C2 - 25392419
AN - SCOPUS:84941124146
SN - 0305-1048
VL - 43
SP - D956-D962
JO - Nucleic Acids Research
JF - Nucleic Acids Research
IS - D1
ER -