AGE/RAGE signalling regulation by miRNAs: Associations with diabetic complications and therapeutic potential

Christina Piperi, Athanasios Goumenos, Christos Adamopoulos, Athanasios G. Papavassiliou

Research output: Contribution to journalShort surveypeer-review

65 Scopus citations

Abstract

Excessive formation of advanced glycation end-products (AGEs) presents the most important mechanism of metabolic memory that underlies the pathophysiology of chronic diabetic complications. Independent of the level of hyperglycaemia, AGEs mediate intracellular glycation of the mitochondrial respiratory chain proteins leading to excessive production of reactive oxygen species (ROS) and amplification of their formation. Additionally, AGEs trigger intracellular damage via activation of the receptor for AGEs (RAGE) signalling axis that leads to elevation of cytosolic ROS, nuclear factor kappaB (NF-κB) activation, increased expression of adhesion molecules and cytokines, induction of oxidative and endoplasmic reticulum stress. Recent studies have identified novel microRNAs (miRNAs) involved in the regulation of AGE/RAGE signalling in the context of diabetic micro- and macrovascular complications. The aim of this review is to discuss the emerging role of miRNAs on AGE/RAGE pathway and the potential use of several miRNAs as novel therapeutic targets.

Original languageEnglish
Pages (from-to)197-201
Number of pages5
JournalInternational Journal of Biochemistry and Cell Biology
Volume60
DOIs
StatePublished - Mar 2015
Externally publishedYes

Keywords

  • AGE/RAGE signalling
  • Diabetes
  • MiRNAs
  • Therapy

Fingerprint

Dive into the research topics of 'AGE/RAGE signalling regulation by miRNAs: Associations with diabetic complications and therapeutic potential'. Together they form a unique fingerprint.

Cite this