Age-related macular degeneration and the aging eye

Rita Ehrlich, Alon Harris, Nisha S. Kheradiya, Diana M. Winston, Thomas A. Ciulla, Barbara Wirostko

Research output: Contribution to journalReview articlepeer-review

82 Scopus citations


Age-related macular degeneration (AMD) is an ocular disease that causes damage to the retinal macula, mostly in the elderly. Normal aging processes can lead to structural and blood flow changes that can predispose patients to AMD, although advanced age does not inevitably cause AMD. In this review, we describe changes that occur in the macular structure, such as the retinal pigment epithelium and Bruch's membrane, with advancing age and in AMD. The role of genetics in AMD and age-related changes in ocular blood flow that may play a role in the pathogenesis of AMD are also discussed. Understanding the pathophysiology of AMD development can help guide future research to further comprehend this disease and to develop better treatments to prevent its irreversible central vision loss in the elderly.

Original languageEnglish
Pages (from-to)473-482
Number of pages10
JournalClinical Interventions in Aging
Issue number3
StatePublished - 2008
Externally publishedYes


  • Age-related macular degeneration
  • Aging
  • Blood flow
  • Eye
  • Macula
  • Retina
  • Vision


Dive into the research topics of 'Age-related macular degeneration and the aging eye'. Together they form a unique fingerprint.

Cite this