Age-related gliosis in the white matter of mice

Roderick T. Bronson; Ruth D. Lipman; David E. Harrison

doi:10.1016/0006-8993(93)90864-J

Age-related gliosis in the white matter of mice

Roderick T. Bronson, Ruth D. Lipman, David E. Harrison

Research output: Contribution to journal › Article › peer-review

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Abstract

A histopathologic study of the brains from 96 mice, ranging in age from 3 to 57 months in age, documents an age-associated increase in hupertrophic astrocytes in white matter. This report of gliosis is distinct from previously reported proliferation of glial cells in the grey matter. Four genotypes, CBA/HT6J, C57BL/6J, B6CBAT6F₁J, and B6C3F₁ were positive for this age-related lesion. Most very old mice utilized in this study were calorically restricted, a dietary manipulation long known to result in increased longevity in rodents. Caloric restriction appears to delay the age associated increase of this lesion. Immunoperoxidase staining for the astrocycte-specific glial fibrillary acidic protein (GFAP) confirmed the progressive increase in the density of stainable astrocytes with increase in age. GFAP staining of white matter increased in both diet groups with age. These findings present an interesting model for the study of aberrant cellular activity and perhaps neurodegeneration, modulated by caloric restriction.

Original language	English
Pages (from-to)	124-128
Number of pages	5
Journal	Brain Research
Volume	609
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(93)90864-J
State	Published - 23 Apr 1993
Externally published	Yes

Keywords

Aging
Brain
Caloric restriction
Gliosis
Mouse
White matter

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title = "Age-related gliosis in the white matter of mice",

abstract = "A histopathologic study of the brains from 96 mice, ranging in age from 3 to 57 months in age, documents an age-associated increase in hupertrophic astrocytes in white matter. This report of gliosis is distinct from previously reported proliferation of glial cells in the grey matter. Four genotypes, CBA/HT6J, C57BL/6J, B6CBAT6F1J, and B6C3F1 were positive for this age-related lesion. Most very old mice utilized in this study were calorically restricted, a dietary manipulation long known to result in increased longevity in rodents. Caloric restriction appears to delay the age associated increase of this lesion. Immunoperoxidase staining for the astrocycte-specific glial fibrillary acidic protein (GFAP) confirmed the progressive increase in the density of stainable astrocytes with increase in age. GFAP staining of white matter increased in both diet groups with age. These findings present an interesting model for the study of aberrant cellular activity and perhaps neurodegeneration, modulated by caloric restriction.",

keywords = "Aging, Brain, Caloric restriction, Gliosis, Mouse, White matter",

author = "Bronson, {Roderick T.} and Lipman, {Ruth D.} and Harrison, {David E.}",

note = "Funding Information: Acknowledgements. This research was supported by NIH Grants AG 07747, AG06232, AG 00594, and in part from Federal funds from the US Department of Agriculture, Agriculture Research Service under contract number 53-3K06-0-1. The contents of this publication do not necessarily reflect the views or policies of the US Department of Agriculture nor of the National Institutes of Health, nor does mention of trade names, commercial products or organizations imply endorsement by the US Government. We would like to thank Dr. John Sundberg for establishing the immunoperoxidase capabilities of the Histology Service of The Jackson Laboratory, and Ms. Ann Higgins, HT (ASCP) for performing most of the excellent histotech-nologic work required for this study.",

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AU - Harrison, David E.

N1 - Funding Information: Acknowledgements. This research was supported by NIH Grants AG 07747, AG06232, AG 00594, and in part from Federal funds from the US Department of Agriculture, Agriculture Research Service under contract number 53-3K06-0-1. The contents of this publication do not necessarily reflect the views or policies of the US Department of Agriculture nor of the National Institutes of Health, nor does mention of trade names, commercial products or organizations imply endorsement by the US Government. We would like to thank Dr. John Sundberg for establishing the immunoperoxidase capabilities of the Histology Service of The Jackson Laboratory, and Ms. Ann Higgins, HT (ASCP) for performing most of the excellent histotech-nologic work required for this study.

PY - 1993/4/23

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N2 - A histopathologic study of the brains from 96 mice, ranging in age from 3 to 57 months in age, documents an age-associated increase in hupertrophic astrocytes in white matter. This report of gliosis is distinct from previously reported proliferation of glial cells in the grey matter. Four genotypes, CBA/HT6J, C57BL/6J, B6CBAT6F1J, and B6C3F1 were positive for this age-related lesion. Most very old mice utilized in this study were calorically restricted, a dietary manipulation long known to result in increased longevity in rodents. Caloric restriction appears to delay the age associated increase of this lesion. Immunoperoxidase staining for the astrocycte-specific glial fibrillary acidic protein (GFAP) confirmed the progressive increase in the density of stainable astrocytes with increase in age. GFAP staining of white matter increased in both diet groups with age. These findings present an interesting model for the study of aberrant cellular activity and perhaps neurodegeneration, modulated by caloric restriction.

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Age-related gliosis in the white matter of mice

Abstract

Keywords

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