Affected-sib-pair analyses of bipolar disorder using data on chromosome 18

Fatemeh Haghighi; Wentian Li; Cathy S.J. Fann

doi:10.1002/(SICI)1098-2272(1997)14:6<641::AID-GEPI15>3.0.CO;2-Q

Affected-sib-pair analyses of bipolar disorder using data on chromosome 18

Fatemeh Haghighi, Wentian Li, Cathy S.J. Fann

Research output: Contribution to journal › Article › peer-review

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Abstract

Our aim was to analyze the GAW10 bipolar data on chromosome 18, using three well-known affected-sib-pair methods. Analyses were carried out on both individual and combined data sets. In these analyses we defined the affected phenotype to include only individuals with diagnosis of bipolar I. We observed suggestive evidence for linkage to a few markers on the peri- centromeric region of chromosome 18. In the COLUMBIA data set, D18S45 showed statistically significant results (p-value ≤ 0.001). Also for the combined analyses, D18S53 gave a consistently significant linkage signal.

Original language	English
Pages (from-to)	641-646
Number of pages	6
Journal	Genetic Epidemiology
Volume	14
Issue number	6
DOIs	https://doi.org/10.1002/(SICI)1098-2272(1997)14:6<641::AID-GEPI15>3.0.CO;2-Q
State	Published - 1997
Externally published	Yes

Keywords

Affected sibpair
Bipolar disorder
Chromosome 18
Meta analysis

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10.1002/(SICI)1098-2272(1997)14:6<641::AID-GEPI15>3.0.CO;2-Q

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abstract = "Our aim was to analyze the GAW10 bipolar data on chromosome 18, using three well-known affected-sib-pair methods. Analyses were carried out on both individual and combined data sets. In these analyses we defined the affected phenotype to include only individuals with diagnosis of bipolar I. We observed suggestive evidence for linkage to a few markers on the peri- centromeric region of chromosome 18. In the COLUMBIA data set, D18S45 showed statistically significant results (p-value ≤ 0.001). Also for the combined analyses, D18S53 gave a consistently significant linkage signal.",

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AU - Haghighi, Fatemeh

AU - Li, Wentian

AU - Fann, Cathy S.J.

PY - 1997

Y1 - 1997

N2 - Our aim was to analyze the GAW10 bipolar data on chromosome 18, using three well-known affected-sib-pair methods. Analyses were carried out on both individual and combined data sets. In these analyses we defined the affected phenotype to include only individuals with diagnosis of bipolar I. We observed suggestive evidence for linkage to a few markers on the peri- centromeric region of chromosome 18. In the COLUMBIA data set, D18S45 showed statistically significant results (p-value ≤ 0.001). Also for the combined analyses, D18S53 gave a consistently significant linkage signal.

AB - Our aim was to analyze the GAW10 bipolar data on chromosome 18, using three well-known affected-sib-pair methods. Analyses were carried out on both individual and combined data sets. In these analyses we defined the affected phenotype to include only individuals with diagnosis of bipolar I. We observed suggestive evidence for linkage to a few markers on the peri- centromeric region of chromosome 18. In the COLUMBIA data set, D18S45 showed statistically significant results (p-value ≤ 0.001). Also for the combined analyses, D18S53 gave a consistently significant linkage signal.

KW - Affected sibpair

KW - Bipolar disorder

KW - Chromosome 18

KW - Meta analysis

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JO - Genetic Epidemiology

JF - Genetic Epidemiology

IS - 6

ER -

Affected-sib-pair analyses of bipolar disorder using data on chromosome 18

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Keywords

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