Aerosolized hyaluronan limits airspace enlargement in a mouse model of cigarette smoke-induced pulmonary emphysema

Jerome O. Cantor; Joseph M. Cerreta; Marcos Ochoa; Shuren Ma; Tony Chow; Gabriele Grunig; Gerard M. Turino

doi:10.1080/01902140590918669

Aerosolized hyaluronan limits airspace enlargement in a mouse model of cigarette smoke-induced pulmonary emphysema

Jerome O. Cantor, Joseph M. Cerreta, Marcos Ochoa, Shuren Ma, Tony Chow, Gabriele Grunig, Gerard M. Turino

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

This study was designed to determine if aerosolized hyaluronan (HA) could prevent airspace enlargement and elastic fiber injury in a mouse model of cigarette smoke-induced pulmonary emphysema. Compared to untreated/smoked controls, HA-treated animals showed statistically significant reductions in mean linear intercept (54 versus 65 μm; P < .001) and elastic fiber breakdown products (desmosine and isodesmosine) in bronchoalveolar lavage fluid (0.3 versus 7.0 ng/mL; P < .05). As in previous studies, the aerosolized HA showed preferential binding to elastic fibers, suggesting that it may protect them from injury. These findings support further investigation of the potential use of HA as a treatment for pulmonary emphysema.

Original language	English
Pages (from-to)	417-430
Number of pages	14
Journal	Experimental Lung Research
Volume	31
Issue number	4
DOIs	https://doi.org/10.1080/01902140590918669
State	Published - May 2005

Keywords

Cigarette smoke
Elastase
Elastic fibers
Emphysema
Hyaluronan

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title = "Aerosolized hyaluronan limits airspace enlargement in a mouse model of cigarette smoke-induced pulmonary emphysema",

abstract = "This study was designed to determine if aerosolized hyaluronan (HA) could prevent airspace enlargement and elastic fiber injury in a mouse model of cigarette smoke-induced pulmonary emphysema. Compared to untreated/smoked controls, HA-treated animals showed statistically significant reductions in mean linear intercept (54 versus 65 μm; P < .001) and elastic fiber breakdown products (desmosine and isodesmosine) in bronchoalveolar lavage fluid (0.3 versus 7.0 ng/mL; P < .05). As in previous studies, the aerosolized HA showed preferential binding to elastic fibers, suggesting that it may protect them from injury. These findings support further investigation of the potential use of HA as a treatment for pulmonary emphysema.",

keywords = "Cigarette smoke, Elastase, Elastic fibers, Emphysema, Hyaluronan",

author = "Cantor, {Jerome O.} and Cerreta, {Joseph M.} and Marcos Ochoa and Shuren Ma and Tony Chow and Gabriele Grunig and Turino, {Gerard M.}",

note = "Funding Information: Received 16 June 2004; accepted 21 September 2004. This work was supported by NHLBI HL68383, the Ned Doyle Foundation, the Charles A. Mastronardi Fund, the Franklyn Bracken Fund, and the James P. Mara Center for Lung Disease at the St. Luke{\textquoteright}s–Roosevelt Hospital Center. Address correspondence to Jerome O. Cantor, MD, St. John{\textquoteright}s University (SAH 128), 8000 Utopia Parkway, Jamaica, New York 11439, USA. E-mail: cantorj@stjohns.edu",

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doi = "10.1080/01902140590918669",

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AU - Cantor, Jerome O.

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AU - Ochoa, Marcos

AU - Ma, Shuren

AU - Chow, Tony

AU - Grunig, Gabriele

AU - Turino, Gerard M.

N1 - Funding Information: Received 16 June 2004; accepted 21 September 2004. This work was supported by NHLBI HL68383, the Ned Doyle Foundation, the Charles A. Mastronardi Fund, the Franklyn Bracken Fund, and the James P. Mara Center for Lung Disease at the St. Luke’s–Roosevelt Hospital Center. Address correspondence to Jerome O. Cantor, MD, St. John’s University (SAH 128), 8000 Utopia Parkway, Jamaica, New York 11439, USA. E-mail: cantorj@stjohns.edu

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AB - This study was designed to determine if aerosolized hyaluronan (HA) could prevent airspace enlargement and elastic fiber injury in a mouse model of cigarette smoke-induced pulmonary emphysema. Compared to untreated/smoked controls, HA-treated animals showed statistically significant reductions in mean linear intercept (54 versus 65 μm; P < .001) and elastic fiber breakdown products (desmosine and isodesmosine) in bronchoalveolar lavage fluid (0.3 versus 7.0 ng/mL; P < .05). As in previous studies, the aerosolized HA showed preferential binding to elastic fibers, suggesting that it may protect them from injury. These findings support further investigation of the potential use of HA as a treatment for pulmonary emphysema.

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KW - Elastase

KW - Elastic fibers

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JO - Experimental Lung Research

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ER -

Aerosolized hyaluronan limits airspace enlargement in a mouse model of cigarette smoke-induced pulmonary emphysema

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Keywords

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