Adverse pregnancy outcomes in relation to water contamination, santa clara county, California, 1980-1981

Margaret Deane, Shanna H. Swan, John A. Harris, David M. Epstein, Raymond R. Neutra

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

An epidemiologic study was conducted to investigate a suspected cluster of adverse outcomes of pregnancies conceived in 1980-1981 among women who resided in a census tract in Santa Clara County, California that was thought to be exposed to drinking water from a well contaminated by an organic solvent, trichloroethane. A comparison census tract that received water from a different source was selected on the basis of demographic comparability. The cluster was confirmed; the odds ratio for spontaneous abortion was 2.3 (95% confidence interval (CI) 1.3-4.2) after adjustment by multiple logistic regression for maternal risk factors, including maternal age, alcohol consumption, smoking, and prior fetal loss. The relative risk for congenital malformations was 3.1 (95% CI 1.1-10.4). Because of the lack of precise information on the timing and extent of contamination, the pattern of spontaneous abortion rates throughout the study period cannot be used to either support or refute a causal inference.

Original languageEnglish
Pages (from-to)894-904
Number of pages11
JournalAmerican Journal of Epidemiology
Volume129
Issue number5
DOIs
StatePublished - May 1989
Externally publishedYes

Keywords

  • Abnormalities
  • Abortion
  • Hydrocarbons, chlorinated
  • Pregnancy
  • Teratogens
  • Water pollution, chemical

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