TY - JOUR
T1 - Adverse environmental conditions influence age-related innate immune responsiveness
AU - May, Linda
AU - van den Biggelaar, Anita H.J.
AU - van Bodegom, David
AU - Meij, Hans J.
AU - de Craen, Anton J.M.
AU - Amankwa, Joseph
AU - Frölich, Marijke
AU - Kuningas, Maris
AU - Westendorp, Rudi G.J.
N1 - Funding Information:
This research was supported by the Netherlands Foundation for the advancements of Tropical Research (grant number WOTRO 93-467), the Netherlands Organization for Scientific Research (NWO 051-14-050), the EU funded Network of Excellence LifeSpan (FP6 036894), the Netherlands Genomics Initiative/Netherlands Organization for Scientific Research (NWO) (050-60810) and the Stichting Dioraphte. We want to thank all people who were part of the research team. Furthermore we want to thank Margo van Schie-Troost and Marja Kersbergen-van Oostrom for their work on the cytokine assays.
PY - 2009/5/30
Y1 - 2009/5/30
N2 - Background-: The innate immune system plays an important role in the recognition and induction of protective responses against infectious pathogens, whilst there is increasing evidence for a role in mediating chronic inflammatory diseases at older age. Despite indications that environmental conditions can influence the senescence process of the adaptive immune system, it is not known whether the same holds true for the innate immune system. Therefore we studied whether age-related innate immune responses are similar or differ between populations living under very diverse environmental conditions. Methods-: We compared cross-sectional age-related changes in ex vivo innate cytokine responses in a population living under affluent conditions in the Netherlands (age 20-68 years old, n = 304) and a population living under adverse environmental conditions in Ghana (age 23-95 years old, n = 562). Results-: We found a significant decrease inLPS-induced Interleukin (IL)-10 and Tumor Necrosis Factor (TNF) production with age in the Dutch population. In Ghana a similar age-related decline in IL-10 responses to LPS, as well as to zymosan, or LPS plus zymosan, was observed. TNF production, however, did not show an age-associated decline, but increased significantly with age in response to co-stimulation with LPS and zymosan. Conclusion-: We conclude that the decline in innate cytokine responses is an intrinsic ageing phenomenon, while pathogen exposure and/or selective survival drive pro-inflammatory responses under adverse living conditions.
AB - Background-: The innate immune system plays an important role in the recognition and induction of protective responses against infectious pathogens, whilst there is increasing evidence for a role in mediating chronic inflammatory diseases at older age. Despite indications that environmental conditions can influence the senescence process of the adaptive immune system, it is not known whether the same holds true for the innate immune system. Therefore we studied whether age-related innate immune responses are similar or differ between populations living under very diverse environmental conditions. Methods-: We compared cross-sectional age-related changes in ex vivo innate cytokine responses in a population living under affluent conditions in the Netherlands (age 20-68 years old, n = 304) and a population living under adverse environmental conditions in Ghana (age 23-95 years old, n = 562). Results-: We found a significant decrease inLPS-induced Interleukin (IL)-10 and Tumor Necrosis Factor (TNF) production with age in the Dutch population. In Ghana a similar age-related decline in IL-10 responses to LPS, as well as to zymosan, or LPS plus zymosan, was observed. TNF production, however, did not show an age-associated decline, but increased significantly with age in response to co-stimulation with LPS and zymosan. Conclusion-: We conclude that the decline in innate cytokine responses is an intrinsic ageing phenomenon, while pathogen exposure and/or selective survival drive pro-inflammatory responses under adverse living conditions.
UR - https://www.scopus.com/pages/publications/67649277650
U2 - 10.1186/1742-4933-6-7
DO - 10.1186/1742-4933-6-7
M3 - Article
AN - SCOPUS:67649277650
SN - 1742-4933
VL - 6
JO - Immunity and Ageing
JF - Immunity and Ageing
M1 - 7
ER -