Adverse Effects of Nondepolarising Neuromuscular Blocking Agents: Incidence, Prevention and Management

Mark Abel, W. Jeffrey Book, James B. Eisenkraft

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Nondepolarising muscle relaxants block neuromuscular transmission, acting as antagonists of the nicotinic receptors at the neuromuscular junction. Their undesired effects are frequently caused by interaction with acetylcholine receptors outside this junction, and autonomic cardiovascular effects may result. Other adverse effects include anaphylactic or anaphylactoid reactions, and histamine release. Various disease states may present specific considerations in the use of nondepolarising muscle relaxants. Although many complications of these drugs (such as prolonged block or resistance) are easily treated, others may necessitate immediate intervention and vigorous therapy. Careful selection of an appropriate relaxant for a particular patient will usually prevent the occurrence of complications.

Original languageEnglish
Pages (from-to)420-438
Number of pages19
JournalDrug Safety
Volume10
Issue number6
DOIs
StatePublished - Jun 1994

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