Advancing personalized prognosis in atypical and anaplastic meningiomas through interpretable machine learning models

Mert Karabacak, Pemla Jagtiani, Alejandro Carrasquilla, Raj K. Shrivastava, Konstantinos Margetis

Research output: Contribution to journalArticlepeer-review


Purpose: The primary purpose of this study was to utilize machine learning (ML) models to create a web application that can predict survival outcomes for patients diagnosed with atypical and anaplastic meningiomas. Methods: In this retrospective cohort study, patients diagnosed with WHO grade II and III meningiomas were selected from the National Cancer Database (NCDB) to analyze survival outcomes at 12, 36, and 60 months. Five machine learning algorithms - TabPFN, TabNet, XGBoost, LightGBM, and Random Forest were employed and optimized using the Optuna library for hyperparameter tuning. The top-performing models were then deployed into our web-based application. Results: From the NCDB, 12,197 adult patients diagnosed with histologically confirmed WHO grade II and III meningiomas were retrieved. The mean age was 61 (± 20), and 6,847 (56.1%) of these were females. Performance evaluation indicated that the top-performing models for each outcome were the models built with the TabPFN algorithm. The TabPFN models yielded area under the receiver operating characteristic (AUROC) values of 0.805, 0.781, and 0.815 in predicting 12-, 36-, and 60-month mortality, respectively. Conclusion: With the continuous growth of neuro-oncology data, ML algorithms act as key tools in predicting survival outcomes for WHO grade II and III meningioma patients. By incorporating these interpretable models into a web application, we can practically utilize them to improve risk evaluation and prognosis for meningioma patients.

Original languageEnglish
Pages (from-to)671-681
Number of pages11
JournalJournal of Neuro-Oncology
Issue number3
StatePublished - Sep 2023
Externally publishedYes


  • Artificial intelligence
  • Machine learning
  • Meningioma
  • Personalized medicine
  • Survival
  • Web application


Dive into the research topics of 'Advancing personalized prognosis in atypical and anaplastic meningiomas through interpretable machine learning models'. Together they form a unique fingerprint.

Cite this