Advancing beyond the twists and turns of T cell exhaustion in cancer

Verena van der Heide; Etienne Humblin; Abishek Vaidya; Alice Oliffson Kamphorst

doi:10.1126/scitranslmed.abo4997

Advancing beyond the twists and turns of T cell exhaustion in cancer

Verena van der Heide
, Etienne Humblin
, Abishek Vaidya
, Alice Oliffson Kamphorst

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Chronic antigen stimulation leads to T cell exhaustion. Nutrient restrictions and other suppressive factors in the tumor microenvironment further exacerbate T cell dysfunction. Better understanding of heterogeneity and dynamics of exhausted CD8 T cells will guide novel therapies that modulate T cell differentiation to achieve more effective antitumor responses.

Original language	English
Article number	eabo4997
Journal	Science Translational Medicine
Volume	14
Issue number	670
DOIs	https://doi.org/10.1126/scitranslmed.abo4997
State	Published - 9 Nov 2022

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title = "Advancing beyond the twists and turns of T cell exhaustion in cancer",

abstract = "Chronic antigen stimulation leads to T cell exhaustion. Nutrient restrictions and other suppressive factors in the tumor microenvironment further exacerbate T cell dysfunction. Better understanding of heterogeneity and dynamics of exhausted CD8 T cells will guide novel therapies that modulate T cell differentiation to achieve more effective antitumor responses.",

author = "\{van der Heide\}, Verena and Etienne Humblin and Abishek Vaidya and Kamphorst, \{Alice Oliffson\}",

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AU - Vaidya, Abishek

AU - Kamphorst, Alice Oliffson

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AB - Chronic antigen stimulation leads to T cell exhaustion. Nutrient restrictions and other suppressive factors in the tumor microenvironment further exacerbate T cell dysfunction. Better understanding of heterogeneity and dynamics of exhausted CD8 T cells will guide novel therapies that modulate T cell differentiation to achieve more effective antitumor responses.

UR - https://www.scopus.com/pages/publications/85141503100

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M3 - Article

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JF - Science Translational Medicine

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Advancing beyond the twists and turns of T cell exhaustion in cancer

Abstract

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