Advancing beyond the twists and turns of T cell exhaustion in cancer

Verena van der Heide, Etienne Humblin, Abishek Vaidya, Alice Oliffson Kamphorst

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic antigen stimulation leads to T cell exhaustion. Nutrient restrictions and other suppressive factors in the tumor microenvironment further exacerbate T cell dysfunction. Better understanding of heterogeneity and dynamics of exhausted CD8 T cells will guide novel therapies that modulate T cell differentiation to achieve more effective antitumor responses.

Original languageEnglish
Article numbereabo4997
JournalScience Translational Medicine
Volume14
Issue number670
DOIs
StatePublished - 9 Nov 2022

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