Advancements in Nanomedicine for Multiple Myeloma

Alexandre Detappe, Mark Bustoros, Tarek H. Mouhieddine, P. Peter Ghoroghchian

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

In the past decades, considerable progress has been made in our understanding and treatment of multiple myeloma. Several challenges remain including our abilities to longitudinally image tumor responses to treatment, to combine various therapeutic agents with different mechanisms of action but with overlapping toxicities, and to efficiently harness the power of the immune system to augment remission and/or to induce permanent cures. Nanomedicine may help to address many of these outstanding issues, affording novel diagnostic capabilities and offering disruptive technologies that promise to revolutionize treatment. Here, we review recent developments and the future of nanomedicine for multiple myeloma, highlighting new considerations in nanoparticle designs that may help to augment active targeting, to facilitate longitudinal imaging, and to improve drug delivery.

Original languageEnglish
Pages (from-to)560-574
Number of pages15
JournalTrends in Molecular Medicine
Volume24
Issue number6
DOIs
StatePublished - Jun 2018
Externally publishedYes

Keywords

  • biomarkers
  • drug delivery
  • imaging
  • multiple myeloma
  • nanomedicine

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