Advanced Glycation Endproducts in Diabetes and Diabetic Complications

Helen Vlassara; Gary E. Striker

doi:10.1016/j.ecl.2013.07.005

Advanced Glycation Endproducts in Diabetes and Diabetic Complications

Helen Vlassara, Gary E. Striker

Research output: Contribution to journal › Review article › peer-review

133 Scopus citations

Abstract

This review presents insights from studies of advanced glycation end products (AGEs) in humans and mice. Although the emphasis is on the effects of exogenous AGEs and the suppression of specific host defense mechanisms, AGEs are also formed intracellularly, where they may contribute to several normal intracellular functions. It is only when the overall levels of AGEs in the extracellular and the intracellular spaces exceeds the ability of the native antioxidant (and AGE) defenses that they pose a problem.

Original language	English
Pages (from-to)	697-719
Number of pages	23
Journal	Endocrinology and Metabolism Clinics of North America
Volume	42
Issue number	4
DOIs	https://doi.org/10.1016/j.ecl.2013.07.005
State	Published - Dec 2013

Keywords

Advanced glycation endproduct
Diabetes
Insulin resistance
Metabolism

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10.1016/j.ecl.2013.07.005

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Advanced Glycation Endproducts in Diabetes and Diabetic Complications

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Keywords

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