TY - GEN
T1 - Advanced glycation end product homeostasis
T2 - Exogenous oxidants and innate defenses
AU - Vlassara, Helen
AU - Uribarri, Jaime
AU - Cai, Weijing
AU - Striker, Gary
PY - 2008/4
Y1 - 2008/4
N2 - Increased oxidative stress (OS) underlies many chronic diseases prevalent in aging. Data in humans confirm the hypothesis that advanced glycation end products (AGEs) and other oxidants derived from the diet may be major contributors to increased OS in normal adults as well as those with diabetes mellitus or kidney failure. Mice fed a diet with a lowered (approximately 50%) content of AGEs or a typical calorie-restricted (CR) diet, accumulated a smaller amount of AGEs, maintained normal levels of AGE receptor-1 (AGER1), and did not have increased oxidant stress or cardiac or kidney fibrosis with aging. However, the findings in mice fed a CR diet with an increased content of AGEs resembled those in mice fed a nonrestricted diet that had the usual higher content of AGEs. Thus, there was an inverse correlation between the dietary AGE content, the AGER1 to receptor for AGE (RAGE) ratio, OS, organ damage, and life span. In both humans and mice, there was an inverse correlation between the AGER1 to RAGE ratio and the levels of OS.
AB - Increased oxidative stress (OS) underlies many chronic diseases prevalent in aging. Data in humans confirm the hypothesis that advanced glycation end products (AGEs) and other oxidants derived from the diet may be major contributors to increased OS in normal adults as well as those with diabetes mellitus or kidney failure. Mice fed a diet with a lowered (approximately 50%) content of AGEs or a typical calorie-restricted (CR) diet, accumulated a smaller amount of AGEs, maintained normal levels of AGE receptor-1 (AGER1), and did not have increased oxidant stress or cardiac or kidney fibrosis with aging. However, the findings in mice fed a CR diet with an increased content of AGEs resembled those in mice fed a nonrestricted diet that had the usual higher content of AGEs. Thus, there was an inverse correlation between the dietary AGE content, the AGER1 to receptor for AGE (RAGE) ratio, OS, organ damage, and life span. In both humans and mice, there was an inverse correlation between the AGER1 to RAGE ratio and the levels of OS.
KW - AGE receptor-1
KW - Caloric restriction
KW - Dietary AGE restriction
KW - Oxidant stress
KW - RAGE
KW - p66
UR - http://www.scopus.com/inward/record.url?scp=42549089560&partnerID=8YFLogxK
U2 - 10.1196/annals.1433.055
DO - 10.1196/annals.1433.055
M3 - Conference contribution
C2 - 18448795
AN - SCOPUS:42549089560
SN - 9781573317
SN - 9789781573316
T3 - Annals of the New York Academy of Sciences
SP - 46
EP - 52
BT - The Maillard Reaction Recent Advances in Food and Biomedical Sciences
PB - Blackwell Publishing Inc.
ER -